3-(巯基甲基)-2-氧代-1-哌啶乙酸合成路线 (共 5 条)
反应条件
1: 70 percent / K2CO3 / 3.5 h / 50 °C
2: 1.) aq. NaOH, 2.) acetic anhydride / 1.) MeOH, 3 d, 2.) reflux, 2 h
3: 75 percent / 72 h
4: 62 percent / CF3COOH / various solvent(s) / 1 h
5: 25percent aq. NH4OH / 1 h
View Scheme
参考文献
Condon; Petrillo Jr.; Ryono; Reid; Neubeck; Puar; Heikes; Sabo; Losee; Cushman; Ondetti
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 250 - 258
反应条件
1: 75 percent / 72 h
2: 62 percent / CF3COOH / various solvent(s) / 1 h
3: 25percent aq. NH4OH / 1 h
View Scheme
参考文献
Condon; Petrillo Jr.; Ryono; Reid; Neubeck; Puar; Heikes; Sabo; Losee; Cushman; Ondetti
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 250 - 258
反应条件
1: 1.) aq. NaOH, 2.) acetic anhydride / 1.) MeOH, 3 d, 2.) reflux, 2 h
2: 75 percent / 72 h
3: 62 percent / CF3COOH / various solvent(s) / 1 h
4: 25percent aq. NH4OH / 1 h
View Scheme
参考文献
Condon; Petrillo Jr.; Ryono; Reid; Neubeck; Puar; Heikes; Sabo; Losee; Cushman; Ondetti
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 250 - 258
反应条件
1: 62 percent / CF3COOH / various solvent(s) / 1 h
2: 25percent aq. NH4OH / 1 h
View Scheme
参考文献
Condon; Petrillo Jr.; Ryono; Reid; Neubeck; Puar; Heikes; Sabo; Losee; Cushman; Ondetti
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 250 - 258
反应条件
ammonium hydroxide
1 h;
参考文献
Condon; Petrillo Jr.; Ryono; Reid; Neubeck; Puar; Heikes; Sabo; Losee; Cushman; Ondetti
Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 250 - 258