2,6-萘啶-1(2H)-酮合成路线 （共 13 条）
反应条件
1: With water; hydrogen bromide in ethanol Reflux; 2: With sodium hydrogencarbonate in water
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2009/158396 A1, 2009 ;
Location in patent: Page/Page column 83-84 ;
反应条件
hydrogen bromide in acetic acid T=55°C; 2 h;
参考文献
Haak, Henk J. W. van den; Plas, Henk C. van der; Veldhuizen, Beb van
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1349 - 1352
反应条件
toluene-4-sulfonic acid in benzene 20 h; Heating;
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Yamanaka, Hiroshi
Chemical & Pharmaceutical Bulletin, 1985 , vol. 33, # 2 p. 626 - 633
反应条件
1: 55 percent / CuI / Pd(PPh3)2Cl2 / triethylamine / 20 h / 100 °C 2: 47 percent / methanol / 5 h / Heating 3: 61 percent / 3N Na2CO3, 15percent H2O2 / acetone / 6 h / Ambient temperature 4: 42 percent / TsOH / benzene / 20 h / Heating View Scheme
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 33, # 2 p. 626 - 633
反应条件
1: 47 percent / methanol / 5 h / Heating 2: 61 percent / 3N Na2CO3, 15percent H2O2 / acetone / 6 h / Ambient temperature 3: 42 percent / TsOH / benzene / 20 h / Heating View Scheme
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 33, # 2 p. 626 - 633
反应条件
1: 61 percent / 3N Na2CO3, 15percent H2O2 / acetone / 6 h / Ambient temperature 2: 42 percent / TsOH / benzene / 20 h / Heating View Scheme
参考文献
Chemical & Pharmaceutical Bulletin, , vol. 33, # 2 p. 626 - 633
反应条件
1: 1) ethyl iodide / 1) 16 h, 2) 50 deg C, 1 h 2: 46 percent / 120 h / Heating 3: 66 percent / 30percent HBr / acetic acid / 2 h / 55 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 18, p. 1349 - 1352
反应条件
1: 46 percent / 120 h / Heating 2: 66 percent / 30percent HBr / acetic acid / 2 h / 55 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 18, p. 1349 - 1352
反应条件
trichlorophosphate 1.5 h; Heating;
参考文献
Haak, Henk J. W. van den; Plas, Henk C. van der; Veldhuizen, Beb van
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1349 - 1352
反应条件
1: in acetonitrile 2 h; Reflux; 2: With sodium tetrahydroborate; ethanol T=0 - 20°C;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2009/158396 A1, 2009 ;
Location in patent: Page/Page column 84-85 ;
