1-[4-(三氟甲基)苯基]丁-1-烯-3-酮合成路线 （共 7 条）
反应条件
sodium hydroxide in water
参考文献
Rajakumar; Rao
Pharmazie, 1994 , vol. 49, # 7 p. 516 - 519
反应条件
ReOCl3(SMe2)(OPPh3); ethyl acetate T=70°C; Meyer-Schuster Rearrangement; 1.5 h;
参考文献
Tetrahedron Letters, , vol. 54, # 6 p. 459 - 461
反应条件
SO3H-MCM-41-NH2 catalyst T=50°C; Aldol condensation; 20 h;
参考文献
Materials Research Bulletin, , vol. 46, # 6 p. 951 - 957
反应条件
1: diethyl ether / 1 h / 20 °C / |Inert atmosphere 2: ReOCl3(SMe2)(OPPh3); ethyl acetate / 1.5 h / 70 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 6 p. 459 - 461
反应条件
1: EtONa / ethanol / 6 h / Heating 2: 2 N NaOH / 2 h / Heating 3: 5 N H2SO4 / 4.5 h / Heating 4: 1.) 50percent NaH / 1.) DMF, RT, 1 h, 2.) DMF, 90 deg C, 4 h View Scheme
参考文献
Kesten, Stephen J.; Degnan, Margaret J.; Hung, Jocelyn; McNamara, Dennis J.; Ortwine, Daniel F.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 19 p. 3429 - 3447
反应条件
1: EtONa / ethanol / 6 h / Heating
2: 2 N NaOH / 2 h / Heating
3: 5 N H2SO4 / 4.5 h / Heating
4: 55 percent / concd HCl, glacial AcOH / 4 h / 85 °C
View Scheme
参考文献
Kesten, Stephen J.; Degnan, Margaret J.; Hung, Jocelyn; McNamara, Dennis J.; Ortwine, Daniel F.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 19 p. 3429 - 3447
反应条件
bis(cyclopentadienyl)titanium dichloride; triethyl amine hydrochloride; zinc in dichloromethane
Inert atmosphere; chemoselective reaction;
参考文献
Ashfeld, Brandon L.; Kosal, Andrew D.
Organic Letters, 2010 , vol. 12, # 1 p. 44 - 47
