反应条件
1: 1.) NaH / 1.) DMF, 50 deg C, 30 min, 2.) DMF, 4 h 2: 25percent MeONa/MeOH / toluene / 4 h / 80 °C 3: 1M aq.NaOH / ethanol / 24 h / Ambient temperature 4: xylene / 48 h / Heating View Scheme
参考文献
Lazer, Edward S.; Miao, Clara K.; Cywin, Charles L.; Sorcek, Ronald; Wong, Hin-Chor; Meng, Zhaoxing; Potocki, Ian; Hoermann, MaryAnn; Snow, Roger J.; Tschantz, Matt A.; Kelly, Terence A.; McNeil, Daniel W.; Coutts, Simon J.; Churchill, Laurie; Graham, Anne G.; David, Eva; Grob, Peter M.; Engel, Wolfhard; Meier, Hans; Trummlitz, Guenter
Journal of Medicinal Chemistry, 1997 , vol. 40, # 6 p. 980 - 989
