4-溴-1,8-萘二甲酸酐合成路线 （共 43 条）
反应条件
1: sodium nitrite; sulfuric acid / 3 h / 20 °C 2: sodium hydroxide / water / 8 h / 80 - 85 °C 3: tin(ll) chloride; hydrogenchloride / water / 2 h / 80 °C View Scheme
参考文献
Tan, Shaoying; Yin, Hong; Chen, Zhuo; Qian, Xuhong; Xu, Yufang
European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 130 - 138
反应条件
1: With sodium hydroxide Heating; 2: With mercury(II) oxide in water; acetic acid 96 h; Heating; 3: With hydrogenchloride 3 h; Heating;
参考文献
Li, Zhigang; Yang, Qing; Qian, Xuhong
Tetrahedron, 2005 , vol. 61, # 36 p. 8711 - 8717
反应条件
2: CuO / 200 - 250 °C 3: (i) NH2OH, NaOAc, (ii) SOCl2 4: aq. H2SO4 View Scheme
参考文献
Nightingale,D.V.; Wagner,W.S.
Journal of Organic Chemistry, 1960 , vol. 25, p. 32 - 34
反应条件
in V methoxymethyl ester T=100°C; 0.133333 h; Microwave irradiation;
参考文献
Zhang, Ye; Feng, Shaobo; Wu, Qiang; Wang, Kai; Yi, Xianghui; Wang, Hengshan; Pan, Yingming
Medicinal Chemistry Research, 2011 , vol. 20, # 6 p. 752 - 759
反应条件
1: 1,4-dioxane / |Reflux 2: potassium fluoride; aluminum oxide; copper(l) iodide / water / 2 h / 95 °C / |Sealed tube View Scheme
参考文献
Bardajee, Ghasem Rezanejade
Tetrahedron Letters, 2013 , vol. 54, # 36 p. 4937 - 4941
反应条件
Behandeln mit Salzsaeure;
参考文献
Francesconi; Bargellini
Gazzetta Chimica Italiana, 1902 , vol. 32 II, p. 86
反应条件
1: 1,4-dioxane / 4 h / |Reflux
2: hydrazine hydrate / 2-methoxy-ethanol / 3 h / |Inert atmosphere; |Reflux
3: hydrogenchloride / ethyl acetate; methanol; N,N-dimethyl-formamide
4: iron sulphate heptahydrate; tert.-butylhydroperoxide / water / 0.33 h / 20 °C
View Scheme
参考文献
Ma, Zhao; Sun, Wei; Chen, Laizhong; Li, Jing; Liu, Zhenzhen; Bai, Haixiu; Zhu, Mengyuan; Du, Lupei; Shi, Xiaodong; Li, Minyong
Chemical Communications, 2013 , vol. 49, # 57 p. 6295 - 6297
反应条件
1.1: aq. NaOH / Heating
1.2: HgO / H2O; acetic acid / 96 h / Heating
1.3: 42 percent / hydrochloric acid / 3 h / Heating
2.1: thionyl chloride / dimethylformamide / 20 h / Heating
3.1: dimethylformamide / 1 h / Heating
View Scheme
参考文献
Li, Zhigang; Yang, Qing; Qian, Xuhong
Tetrahedron, 2005 , vol. 61, # 36 p. 8711 - 8717
反应条件
Multistep reaction. Title compound not separated from byproducts;
参考文献
Moseley, Jonathan D.; Gilday, John P.
Tetrahedron, 2006 , vol. 62, # 19 p. 4690 - 4697
参考文献
Wang, Xin; Chen, Zhuo; Tong, Linjiang; Tan, Shaoying; Zhou, Wei; Peng, Ting; Han, Kun; Ding, Jian; Xie, Hua; Xu, Yufang
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 477 - 486
