顺-4-苄氧基-2-丁烯-1-醇合成路线 （共 20 条）
反应条件
1: cis-1,4-dihydroxy-2-butene With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; Inert atmosphere; 2: benzyl bromide in tetrahydrofuran T=0 - 20°C; 2 h;
参考文献
GLAXO GROUP LIMITED; JOHNS, Brian Alvin; SHOTWELL, John Brad; HAIGH, David
Patent: WO2012/67663 A1, 2012 ;
Location in patent: Page/Page column 60 ;
反应条件
lithium aluminium tetrahydride
参考文献
Naruta, Yoshinori; Nagai, Naoshi; Maruyama, Kazuhiro
Chemistry Letters, 1983 , p. 1383 - 1386
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 0.75 h;
参考文献
Yoshimitsu, Takehiko; Fukumoto, Naoya; Tanaka, Tetsuaki
Journal of Organic Chemistry, 2009 , vol. 74, # 2 p. 696 - 702
反应条件
1: cis-1,4-dihydroxy-2-butene With sodium hydride in tetrahydrofuran T=0 - 20°C; 1 h; Inert atmosphere; 2: benzyl chloride in tetrahydrofuran T=0 - 20°C; 24 h;
参考文献
Dayde, Benedicte; Pierra, Claire; Gosselin, Gilles; Surleraux, Dominique; Ilagouma, Amadou Tidjani; Laborde, Coralie; Volle, Jean-Noel; Virieux, David; Pirat, Jean-Luc
European Journal of Organic Chemistry, 2014 , vol. 2014, # 6 p. 1333 - 1337
反应条件
sodium hydride in tetrahydrofuran T=0 - 20°C; 3 h;
参考文献
Balamurugan, Rengarajan; Kothapalli, Raveendra Babu; Thota, Ganesh Kumar
European Journal of Organic Chemistry, 2011 , # 8 p. 1557 - 1569
反应条件
indium(III) chloride in water; acetonitrile 3 h; Heating;
参考文献
Yadav; Reddy, B.V. Subba; Srinivas; Maiti
Journal of Chemical Research - Part S, 2001 , # 12 p. 528 - 529
反应条件
cerium(III) chloride; sodium iodide in acetonitrile 4.5 h; Ambient temperature;
参考文献
Bartoli, Giuseppe; Bosco, Marcella; Marcantoni, Enrico; Sambri, Letizia; Torregiani, Elisabetta
Synlett, 1998 , # 2 p. 209 - 211
反应条件
methanol; Montmorillonite K-10 clay T=20°C; Methanolytic deprotection;
参考文献
Taniguchi, Takahiko; Kadota, Kohei; Elazab, Adel S.; Ogasawara, Kunio
Synlett, 1999 , # 8 p. 1247 - 1248
反应条件
1: 79 percent / camphorsulfonic acid / benzene / 18 h / Heating 2: LiAlH4, AlCl3 / diethyl ether / 1.) 0 deg C to RT, 30 min; 2.) 2 h View Scheme
参考文献
Journal of the American Chemical Society, , vol. 107, p. 3891
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran Reflux;
参考文献
Tetrahedron Letters, , vol. 50, # 26 p. 3571 - 3573
