顺-4-苄氧基-2-丁烯-1-醇合成路线 （共 20 条）
反应条件
1: sodium hydride / 1,2-dimethoxy-ethane / 0.5 h / 40 °C 2: aq. 5 percent HCl / 5 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 40, # 5 p. 1154 - 1165
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
参考文献
Tetrahedron Letters, , vol. 50, # 26 p. 3571 - 3573
反应条件
hydrogenchloride 5 h; Ambient temperature; Yield given;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 40, # 5 p. 1154 - 1165
反应条件
hydrogen; TMSB; palladium in ethanol T=20°C; P=760 Torr; 22 h;
参考文献
Belotti, Damien; Cantagrel, Guillaume; Combellas, Catherine; Cossy, Janine; Kanoufi, Frederic; Nunige, Sandra
New Journal of Chemistry, 2005 , vol. 29, # 6 p. 761 - 764
反应条件
1: 90 percent / PPh3; DIAD / tetrahydrofuran / 20 °C 2: 74 percent / Et3N; mercaptoacetic acid / CH2Cl2 / 20 °C View Scheme
参考文献
Zhou, Cong-Ying; Yu, Wing-Yiu; Chan, Philip Wai Hong; Che, Chi-Ming
Journal of Organic Chemistry, 2004 , vol. 69, # 21 p. 7072 - 7082
反应条件
Montmorillonite KSF
T=20°C; 8 h;
参考文献
Sampath Kumar; Joyasawal, Sipak; Reddy; Pawan Chakravarthy; Krishna; Yadav
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 8 p. 1686 - 1692
反应条件
tetra-(n-butyl)ammonium iodide; sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide
T=0 - 25°C; 0.5 h; Yield given. Yields of byproduct given;
参考文献
Chakraborty, T. K.; Reddy, G. V.
Journal of the Chemical Society, Chemical Communications, 1989 , p. 251 - 253
反应条件
1: With IPNBSH; triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
T=0 - 23°C; Mitsunobu reaction; 2 h;
2: in 2,2,2-trifluoroethanol; water
T=23°C; 3 h;
参考文献
Movassaghi, Mohammad; Ahmad, Omar K.
Journal of Organic Chemistry, 2007 , vol. 72, # 5 p. 1838 - 1841
反应条件
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
1.2: 5 h
2.1: n-butyllithium / tetrahydrofuran / 4 h / -78 °C / Inert atmosphere
View Scheme
参考文献
GLAXO GROUP LIMITED; JOHNS, Brian Alvin; SHOTWELL, John Brad; HAIGH, David
Patent: WO2012/67663 A1, 2012 ;
反应条件
1: 90 percent / NaH / tetrahydrofuran / 1.5 h / Ambient temperature
2: 88 percent / decahydronaphthalene / 12 h / Heating
View Scheme
参考文献
Bongini, Alessandro; Cardillo, Giuliana; Orena, Mario; Sandri, Sergio; Tomasini, Claudia
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 935 - 940
