1-溴-2,3,4-三氯苯合成路线 （共 5 条）
反应条件
TBCA in trifluoroacetic acid
T=20°C; 0.5 h;
参考文献
De Almeida, Leonardo S.; De Mattos, Marcioc. S.; Esteves, Pierre M.
Synlett, 2013 , vol. 24, # 5 art. no. ST-2012-S0798-L, p. 603 - 606
反应条件
1: With diisopropylamine in tetrahydrofuran; hexane
T=-75°C; 2 h;
2: With n-butyllithium in tetrahydrofuran; diethyl ether; hexane
T=-100°C; 0.25 h; Title compound not separated from byproducts;
参考文献
Schlosser, Manfred; Heiss, Christophe; Marzi, Elena; Scopelliti, Rosario
European Journal of Organic Chemistry, 2006 , # 19 p. 4398 - 4404
反应条件
1,1-dimethylnitroethane; copper(ll) bromide in acetonitrile
T=60°C; Sandmeyer reaction; 0.5 h;
参考文献
Sott, Richard; Hawner, Christine; Johansen, Jon E.
Tetrahedron, 2008 , vol. 64, # 18 p. 4135 - 4142
反应条件
1.1: diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C
1.2: 89 percent / hexane; tetrahydrofuran
2.1: 96 percent / bromine / CCl4 / 12 h / Heating
3.1: diisopropylamine / hexane; tetrahydrofuran / 2 h / -75 °C
3.2: butyllithium / tetrahydrofuran; diethyl ether; hexane / 0.25 h / -100 °C
View Scheme
参考文献
Schlosser, Manfred; Heiss, Christophe; Marzi, Elena; Scopelliti, Rosario
European Journal of Organic Chemistry, 2006 , # 19 p. 4398 - 4404
反应条件
1.1: 96 percent / bromine / CCl4 / 12 h / Heating
2.1: diisopropylamine / hexane; tetrahydrofuran / 2 h / -75 °C
2.2: butyllithium / tetrahydrofuran; diethyl ether; hexane / 0.25 h / -100 °C
View Scheme
参考文献
Schlosser, Manfred; Heiss, Christophe; Marzi, Elena; Scopelliti, Rosario
European Journal of Organic Chemistry, 2006 , # 19 p. 4398 - 4404
