(4S)-4-羟基-L-脯氨酸甲酯合成路线

191280-88-3(2S,4S)-4-羟基-2-(羟甲基)吡咯烷-1-羧酸叔丁酯

参考文献

Jing, Qing; Li, Huiying; Roman, Linda J.; Martasek, Pavel; Poulos, Thomas L.; Silverman, Richard B.
ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 1 p. 56 - 60

24424-99-5二碳酸二叔丁酯+

81102-38-7(4S)-4-羟基-L-脯氨酸甲酯

74844-91-0N-Boc-反式-4-羟基-L-脯氨酸甲酯

参考文献

ACS Medicinal Chemistry Letters, , vol. 5, # 1 p. 56 - 60

81102-38-7(4S)-4-羟基-L-脯氨酸甲酯

618-27-9顺式-4-羟基-L-脯氨酸

参考文献

Madau, Alessandra; Porzi, Gianni; Sandri, Sergio
Tetrahedron Asymmetry, 1996 , vol. 7, # 3 p. 825 - 830

24424-99-5二碳酸二叔丁酯+

81102-38-7(4S)-4-羟基-L-脯氨酸甲酯

74844-91-0N-Boc-反式-4-羟基-L-脯氨酸甲酯

参考文献

Jing, Qing; Li, Huiying; Roman, Linda J.; Martasek, Pavel; Poulos, Thomas L.; Silverman, Richard B.
ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 1 p. 56 - 60

24424-99-5二碳酸二叔丁酯+

81102-38-7(4S)-4-羟基-L-脯氨酸甲酯

74844-91-0N-Boc-反式-4-羟基-L-脯氨酸甲酯

参考文献

Jing, Qing; Li, Huiying; Roman, Linda J.; Martasek, Pavel; Poulos, Thomas L.; Silverman, Richard B.
ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 1 p. 56 - 60

81102-38-7(4S)-4-羟基-L-脯氨酸甲酯

203866-18-6N-Boc-反式-4-氟-L-脯氨酸甲酯

参考文献

Filosa, Rosanna; Holder, Claude; Auberson, Yves P.
Tetrahedron Letters, 2006 , vol. 47, # 50 p. 8929 - 8932

67-56-1甲醇+

618-27-9顺式-4-羟基-L-脯氨酸

81102-38-7(4S)-4-羟基-L-脯氨酸甲酯

参考文献

Dainippon Sumitomo Pharma Co., Ltd.
Patent: EP1659123 A1, 2006 ;
Location in patent: Page/Page column 179 ;

176966-58-8

81102-38-7(4S)-4-羟基-L-脯氨酸甲酯

参考文献

Madau, Alessandra; Porzi, Gianni; Sandri, Sergio
Tetrahedron Asymmetry, 1996 , vol. 7, # 3 p. 825 - 830

177186-30-0

81102-38-7(4S)-4-羟基-L-脯氨酸甲酯

参考文献

Madau, Alessandra; Porzi, Gianni; Sandri, Sergio
Tetrahedron Asymmetry, 1996 , vol. 7, # 3 p. 825 - 830

74844-91-0N-Boc-反式-4-羟基-L-脯氨酸甲酯

81102-38-7(4S)-4-羟基-L-脯氨酸甲酯

参考文献

Owens, Neil W.; Lee, Adrian; Marat, Kirk; Schweizer, Frank
Chemistry - A European Journal, 2009 , vol. 15, # 40 p. 10649 - 10657