N-[4-(2-氯丙酰基)苯基]乙酰胺合成路线 （共 5 条）
反应条件
1: 1) NaH / 1) DMF, room temperature, overnight, 2) DMF, 110 deg C, 3 h 2: 1.) HCl/EtOH, 2.) 6N aq. HCl / 2 h / Heating; 1.) reflux, 2 h, 2.) reflux, 2 h 3: 87 percent / hydrazine hydrate / H2O / 1.5 h / Heating View Scheme
参考文献
Burpitt; Crawford; Davies; Mistry; Mitchell; Pancholi; Coates
Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 6 p. 1689 - 1695
反应条件
1: 1) NaH / 1) DMF, room temperature, overnight, 2) DMF, 110 deg C, 3 h 2: 1.) HCl/EtOH, 2.) 6N aq. HCl / 2 h / Heating; 1.) reflux, 2 h, 2.) reflux, 2 h View Scheme
参考文献
Burpitt; Crawford; Davies; Mistry; Mitchell; Pancholi; Coates
Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 6 p. 1689 - 1695
反应条件
1: 1) NaH / 1) DMF, room temperature, overnight, 2) DMF, 110 deg C, 3 h
2: 1.) HCl/EtOH, 2.) 6N aq. HCl / 2 h / Heating; 1.) reflux, 2 h, 2.) reflux, 2 h
3: 87 percent / hydrazine hydrate / H2O / 1.5 h / Heating
View Scheme
参考文献
Burpitt; Crawford; Davies; Mistry; Mitchell; Pancholi; Coates
Journal of Heterocyclic Chemistry, 1988 , vol. 25, # 6 p. 1689 - 1695
反应条件
1: diethyl malonate With sodium hydride in N,N-dimethyl-formamide
T=50°C; 1.5 h;
2: N-[4-(2-chloro-1-oxopropyl)phenyl]acetamide in N,N-dimethyl-formamide
T=80°C; 3 h;
3: With water in N,N-dimethyl-formamide
参考文献
Boehringer Ingelheim Pharma GmbH and Co. KG
Patent: US7230001 B1, 2007 ;
Location in patent: Page/Page column 87 ;
US 7230001 B1
反应条件
hydrogenchloride in ethanol
参考文献
Laboratoire L. Lafon
Patent: US4963570 A1, 1990 ;
