反应条件
1.1: palladium 10 on activated carbon; hydrogen / ethyl acetate / 4 h / 20 °C
2.1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere
3.1: sodium azide / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere
4.1: palladium 10 on activated carbon; hydrogen; potassium carbonate / methanol / 4 h / 20 °C
5.1: borane-THF / 5 h / Inert atmosphere; Reflux
5.2: 0.5 h / 0 - 20 °C / Inert atmosphere
6.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / Inert atmosphere
7.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere
8.1: pyridine / ethanol / 0.5 h / 20 °C / Inert atmosphere
9.1: borane-THF / tetrahydrofuran / 4 h / 50 °C / Inert atmosphere
10.1: sodium tetrahydroborate / methanol / Inert atmosphere
11.1: hydrogenchloride / methanol; water / Inert atmosphere
View Scheme
参考文献
Pansare, Sunil V.; Paul, Eldho K.
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 10 p. 2119 - 2125