(3aR,7aR)-3,3-二甲基-7a-(2-丙炔-1-基)-3a,4,7,7a-四氢-2-苯并呋喃-1(3H)-酮合成路线 （共 4 条）
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium diisopropyl amide in tetrahydrofuran
T=20°C;
参考文献
Toyota, Masahiro; Matsuura, Kiminori; Yokota, Masahiro; Kimura, Manami; Yonaga, Masahiro; Sugimoto, Hachiro; Ihara, Masataka
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 9 p. 1153 - 1154
反应条件
1.1: H2SO4 / diethyl ether / 20 °C
2.1: aq. NaOH / methanol / 20 °C
3.1: tetrahydrofuran
3.2: aq. H2SO4 / tetrahydrofuran
4.1: LDA; HMPA / tetrahydrofuran / 20 °C
View Scheme
参考文献
Toyota, Masahiro; Matsuura, Kiminori; Yokota, Masahiro; Kimura, Manami; Yonaga, Masahiro; Sugimoto, Hachiro; Ihara, Masataka
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 9 p. 1153 - 1154
反应条件
1.1: tetrahydrofuran
1.2: aq. H2SO4 / tetrahydrofuran
2.1: LDA; HMPA / tetrahydrofuran / 20 °C
View Scheme
参考文献
Toyota, Masahiro; Matsuura, Kiminori; Yokota, Masahiro; Kimura, Manami; Yonaga, Masahiro; Sugimoto, Hachiro; Ihara, Masataka
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 9 p. 1153 - 1154
反应条件
1.1: aq. NaOH / methanol / 20 °C
2.1: tetrahydrofuran
2.2: aq. H2SO4 / tetrahydrofuran
3.1: LDA; HMPA / tetrahydrofuran / 20 °C
View Scheme
参考文献
Toyota, Masahiro; Matsuura, Kiminori; Yokota, Masahiro; Kimura, Manami; Yonaga, Masahiro; Sugimoto, Hachiro; Ihara, Masataka
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 9 p. 1153 - 1154
