2-氯-4-(1-丙炔-1-基)嘧啶合成路线 （共 4 条）
反应条件
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) in toluene
T=60°C; 1 h;
参考文献
Almirall, S.A.; Vidal Juan, Bernat; Alonso Diez, Juan Antonio; Buil Albero, María Antonia; Eastwood, Paul Robert; Esteve Trias, Cristina; Lozoya Toribio, María Estrella; Roberts, Richard Spurring; Vidal Gispert, Laura
Patent: EP2548876 A1, 2013 ;
Location in patent: Paragraph 0693-0696 ;
EP 2548876 A1
反应条件
triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide
T=20°C; Sonogashira coupling reaction; 12 h;
参考文献
YALE UNIVERSITY
Patent: WO2007/38387 A2, 2007 ;
Location in patent: Page/Page column 37-38; 79 ;
反应条件
copper(I) bromide in N,N-dimethyl acetamide; triethylamine
T=130°C; 12 h;
参考文献
YALE UNIVERSITY
Patent: WO2007/38387 A2, 2007 ;
Location in patent: Page/Page column 37-38; 79-80 ;
反应条件
1: 12 percent / CuBr / triethylamine; N,N-dimethyl-acetamide / 12 h / 130 °C
2: HCl / ethanol; H2O / 90 °C
View Scheme
参考文献
Kim, Joseph T.; Hamilton, Andrew D.; Bailey, Christopher M.; Domoal, Robert A.; Wang, Ligong; Anderson, Karen S.; Jorgensen, William L.
Journal of the American Chemical Society, 2006 , vol. 128, # 48 p. 15372 - 15373
