1: With trichlorophosphate in acetonitrile 4 h; Heating / reflux; 2: With sodium carbonate in water; acetonitrile pH=7;

triethylamine in dichloromethane T=0°C; 2 - 3 h;

triethylamine in ethyl acetate T=20°C; 1 h;

1: 2-(3,4-dimethoxyphenyl)-ethylamine; 4-formyl-3,5-dimethoxyphenoxy-Merrifield resin With sodium tris(acetoxy)borohydride in acetic acid; N,N-dimethyl-formamide T=20°C; Solid phase reaction; reductive amination; 69 h; 2: butyric acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide in N,N-dimethyl-formamide T=20°C; Solid phase reaction; acylation; 15 h; 3: With dimethylsulfide; water; trifluoroacetic acid in dichloromethane T=20°C; Solid phase reaction; cleavage of amide; 15 h;

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