3-[[[(1,1-二甲基乙基)二甲基甲硅烷基]氧基]甲基]苯甲醛合成路线 （共 4 条）
反应条件
sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine in dichloromethane
T=0°C; 1 h;
参考文献
MERCK and CO., INC.
Patent: WO2004/58702 A2, 2004 ;
Location in patent: Page 34; 26 ;
WO 2004/058702 A2
反应条件
1: 3-(tert-butyldimethylsilyloxymethyl)bromobenzene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: (4-morpholinyl)methanone in tetrahydrofuran; hexane
T=-78°C; 1 h;
参考文献
Eisai Co., Ltd.
Patent: EP1380562 A1, 2004 ;
Location in patent: Page 112-113 ;
反应条件
1: 53 percent / NaH / tetrahydrofuran
2: 79 percent / MnO2 / CH2Cl2
View Scheme
参考文献
Chen, Li; Tilley, Jefferson; Trilles, Richard V.; Yun, Weiya; Fry, David; Cook, Charles; Rowan, Karen; Schwinge, Virginia; Campbell, Robert
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 2 p. 137 - 140
反应条件
1: imidazole / CH2Cl2
2: MnO2 / tetrahydrofuran / Heating
View Scheme
参考文献
Takeuchi, Kumiko; Kohn, Todd J.; Mais, Dale E.; True, Timothy A.; Wyss, Virginia L.; Jakubowski, Joseph A.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 15 p. 1943 - 1948
