1-[4-(苄氧基)-3-氟苯基]-1-乙酮合成路线 （共 5 条）
反应条件
sodium hydride in N,N-dimethyl-formamide T=60°C; 0.75 h;
参考文献
Machin, Peter J.; Hurst, David N.; Bradshaw, Rachel M.; Blaber, Leslie C.; Burden, David T.; et al.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 11 p. 1570 - 1576
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene T=100°C; Stille coupling;
参考文献
Givens, Richard S.; Stensrud, Kenneth; Conrad, Peter G.; Yousef, Abraham L.; Perera, Chamani; Senadheera, Sanjeewa N.; Heger, Dominik; Wirz, Jakob
Canadian Journal of Chemistry, 2011 , vol. 89, # 3 p. 364 - 384
反应条件
in N-methyl-acetamide; ethyl acetate; mineral oil
参考文献
Hoffmann-La Roche Inc.
Patent: US4649160 A1, 1987 ;
US 4649160 A
反应条件
1: potassium carbonate / acetonitrile / 15 h / 20 °C 2: tetrakis(triphenylphosphine) palladium(0) / toluene / 100 °C View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 89, # 3 p. 364 - 384
反应条件
1: bromine; trifluoroacetic acid / 20 °C 2: potassium carbonate / acetonitrile / 15 h / 20 °C 3: tetrakis(triphenylphosphine) palladium(0) / toluene / 100 °C View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 89, # 3 p. 364 - 384
