5,6-二氨基-1,3-二丙基嘧啶-2,4(1H,3H)-二酮合成路线 （共 32 条）
反应条件
sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride 1) dioxane, H2O, 2) dioxane, H2O, reflux; Multistep reaction;
参考文献
Kyowa Hakko Kogyo Co., Ltd.
Patent: US5484920 A1, 1996 ;
US 5484920 A
反应条件
1: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 4-(N,N-dimethylamino)pyridine, imidazole / dimethylformamide / 3 h / Ambient temperature 2: 4 N aq. NaOH / methanol / 2 h / 60 °C View Scheme
参考文献
Jacobson; Gallo-Rodriguez; Melman; Fischer; Maillard; Van Bergen; Van Galen; Karton
Journal of Medicinal Chemistry, 1993 , vol. 36, # 10 p. 1333 - 1342
反应条件
1: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 4-(N,N-dimethylamino)pyridine, imidazole / dimethylformamide / 3 h / Ambient temperature 2: 4 N aq. NaOH / methanol / 2 h / 60 °C 3: K2CO3 / dimethylformamide / 0.5 h / 60 °C View Scheme
参考文献
Jacobson; Gallo-Rodriguez; Melman; Fischer; Maillard; Van Bergen; Van Galen; Karton
Journal of Medicinal Chemistry, 1993 , vol. 36, # 10 p. 1333 - 1342
反应条件
1: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 4-(N,N-dimethylamino)pyridine, imidazole / dimethylformamide / 3 h / Ambient temperature 2: 4 N aq. NaOH / methanol / 2 h / 60 °C View Scheme
参考文献
Jacobson; Gallo-Rodriguez; Melman; Fischer; Maillard; Van Bergen; Van Galen; Karton
Journal of Medicinal Chemistry, 1993 , vol. 36, # 10 p. 1333 - 1342
反应条件
pyridine Ambient temperature;
参考文献
Jacobson, Kenneth A.; Shi, Dan; Gallo-Rodriguez, Carola; Manning, Malcolm; Mueller, Christa; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2639 - 2644
反应条件
1: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 4-(N,N-dimethylamino)pyridine, imidazole / dimethylformamide / 3 h / Ambient temperature 2: 4 N aq. NaOH / methanol / 2 h / 60 °C View Scheme
参考文献
Jacobson; Gallo-Rodriguez; Melman; Fischer; Maillard; Van Bergen; Van Galen; Karton
Journal of Medicinal Chemistry, 1993 , vol. 36, # 10 p. 1333 - 1342
反应条件
sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride 1) dioxane, H2O, 2) dioxane, H2O, reflux; Multistep reaction;
参考文献
Shimada, Junichi; Koike, Nobuaki; Nonaka, Hiromi; Shiozaki, Shizuo; Yanagawa, Koji; Kanda, Tomoyuki; Kobayashi, Hiroyuki; Ichimura, Michio; Nakamura, Joji; Kase, Hiroshi; Suzuki, Fumio
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 18 p. 2349 - 2352
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in methanol T=20°C; 5 h;
参考文献
Baraldi, Pier Giovanni; Tabrizi, Mojgan Aghazadeh; Preti, Delia; Bovero, Andrea; Romagnoli, Romeo; Fruttarolo, Francesca; Zaid, Naser Abdel; Moorman, Allan R.; Varani, Katia; Gessi, Stefania; Merighi, Stefania; Borea, Pier Andrea
Journal of Medicinal Chemistry, 2004 , vol. 47, # 6 p. 1434 - 1447
反应条件
1: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / 1 h / Ambient temperature 2: 2.5N NaOH / 0.08 h / 70 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 4 p. 487 - 492
反应条件
sodium hydroxide; Ca(OH)2; 1,1'-carbonyldiimidazole in dichloromethane; water
参考文献
US5175291 A1, ;
US 5175291 A
