5,6-二氨基-1,3-二丙基嘧啶-2,4(1H,3H)-二酮合成路线 （共 32 条）
反应条件
1: EDAC / methanol / 5 h / 20 °C 2: aq. NaOH / methanol / 12 h / 70 - 80 °C View Scheme
参考文献
Baraldi, Pier Giovanni; Tabrizi, Mojgan Aghazadeh; Preti, Delia; Bovero, Andrea; Romagnoli, Romeo; Fruttarolo, Francesca; Zaid, Naser Abdel; Moorman, Allan R.; Varani, Katia; Gessi, Stefania; Merighi, Stefania; Borea, Pier Andrea
Journal of Medicinal Chemistry, 2004 , vol. 47, # 6 p. 1434 - 1447
反应条件
sodium hydroxide; diisopropyl-carbodiimide 1.) MeOH, overnight, 2.) DMF, reflux, 15 min; Yield given. Multistep reaction;
参考文献
Daly; Padgett; Shamim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1520 - 1524
反应条件
in methanol; acetic acid
参考文献
Daly; Padgett; Shamim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1520 - 1524
反应条件
1: glacial acetic acid / ethanol / Ambient temperature 2: 93 percent / iodine / 1,2-dimethoxy-ethane / 4 h / 50 °C View Scheme
参考文献
Perumattam, John
Synthetic Communications, 1989 , vol. 19, # 19 p. 3367 - 3370
反应条件
1: 130 °C 2: NaOH / H2O / 1 h / Heating View Scheme
参考文献
Shimada, Junichi; Suzuki, Fumio; Nonaka, Hiromi; Karasawa, Akira; Mizumoto, Hideaki; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 466 - 469
反应条件
thionyl chloride in pyridine; methanol
参考文献
Kyowa Hakko Kogyo Co., Ltd.
Patent: US5290782 A1, 1994 ;
US 5290782 A
反应条件
1: pyridine / 1 h / Ambient temperature 2: 2N aq. NaOH / dioxane / 10 h / Heating View Scheme
参考文献
Shimada; Suzuki; Nonaka; Ishii
Journal of Medicinal Chemistry, 1992 , vol. 35, # 5 p. 924 - 930
参考文献
Erickson, Ronald H.; Hiner, Roger N.; Feeney, Scott W.; Blake, Paul R.; Rzeszotarski, Waclaw J.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1431 - 1435
反应条件
1: 73 percent / acetic acid, sodium acetate / 2 h / Ambient temperature 2: 82 percent / sodium methoxide / 2 h / Heating View Scheme
参考文献
Gatta; Del Giudice; Borioni; Mustazza
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 1 p. 81 - 86
反应条件
1: 88 percent / pyridine / 5 h / Ambient temperature 2: 87 percent / 1 N NaOH / ethanol / 1 h / Heating View Scheme
参考文献
Erickson, Ronald H.; Hiner, Roger N.; Feeney, Scott W.; Blake, Paul R.; Rzeszotarski, Waclaw J.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1431 - 1435
