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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
脑益嗪
合成路线
（共 17 条）
10499-16-8
→
反应条件
81267-65-4
脑益嗪
反应条件
tetramethyl-ammonium iodide; boron trichloride T=-78 - 0°C; 2 h; Inert atmosphere;
参考文献
KaoHsiung Medical University
Patent: US2010/298581 A1, 2010 ;
Location in patent: Page/Page column 6-7 ;
922179-55-3
→
反应条件
81267-65-4
脑益嗪
反应条件
hydrogenchloride; methanol in dichloromethane T=0°C; 48 h;
参考文献
Setchell, Kenneth David Reginald; Sorokin, Victor Dmitrievich
Patent: US2007/27329 A1, 2007 ;
Location in patent: Page/Page column 12 ;
81267-66-5
4-(7-乙酰氧基-2H-苯并吡喃-3-基)苯基乙酸酯
→
反应条件
81267-65-4
脑益嗪
反应条件
1H-imidazole in ethanol 0.75 h; Heating / reflux;
参考文献
Novogen Research Pty Ltd.
Patent: US2005/143588 A1, 2005 ;
Location in patent: Page/Page column 11 ;
1118431-83-6
→
反应条件
81267-65-4
脑益嗪
反应条件
pyridine hydrochloride T=220°C; Inert atmosphere;
参考文献
Gupta, Atul; Ray, Suprabhat
Synthesis, 2008 , # 23 art. no. Z14208SS, p. 3783 - 3786
3682-01-7
→
反应条件
81267-65-4
脑益嗪
反应条件
1: 1.2 g / H2, N-methylpyrrolidinone / 5percent Pd/C / 54 h 2: 0.42 g / benzoyl chloride, DMF / 0.17 h / 100 - 110 °C 3: 0.47 g / imidazole / ethanol / 0.75 h / Heating View Scheme
参考文献
Australian Journal of Chemistry, , vol. 34, # 12 p. 2647 - 2655
108-46-3
间苯二酚
→
反应条件
81267-65-4
脑益嗪
反应条件
1: trifluorormethanesulfonic acid / dichloromethane / 1.5 h / 80 °C 2: sodium hydroxide / water / 4 h / 0 °C 3: copper(ll) bromide / ethyl acetate; chloroform; methanol / 4 h / 70 °C 4: 1H-imidazole / dichloromethane / 1.25 h / 20 °C 5: sodium tetrahydroborate / ethanol / 1 h / 20 °C 6: toluene-4-sulfonic acid / toluene / 0.33 h / 80 °C / |Microwave irradiation 7: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol; water / 80 °C 8: hydrogen fluoride; pyridine / tetrahydrofuran / 5 h / 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 35 p. 5782 - 5786
76240-27-2
7-羟基色满-4-酮
→
反应条件
81267-65-4
脑益嗪
反应条件
1: copper(ll) bromide / ethyl acetate; chloroform; methanol / 4 h / 70 °C 2: 1H-imidazole / dichloromethane / 1.25 h / 20 °C 3: sodium tetrahydroborate / ethanol / 1 h / 20 °C 4: toluene-4-sulfonic acid / toluene / 0.33 h / 80 °C / |Microwave irradiation 5: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol; water / 80 °C 6: hydrogen fluoride; pyridine / tetrahydrofuran / 5 h / 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 35 p. 5782 - 5786
269409-70-3
4-羟基苯硼酸频哪醇酯
→
反应条件
81267-65-4
脑益嗪
反应条件
1: 1H-imidazole / N,N-dimethyl-formamide / 5 h / 20 °C 2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol; water / 80 °C 3: hydrogen fluoride; pyridine / tetrahydrofuran / 5 h / 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 35 p. 5782 - 5786
124887-46-3
→
反应条件
81267-65-4
脑益嗪
反应条件
1: 1H-imidazole / dichloromethane / 1.25 h / 20 °C 2: sodium tetrahydroborate / ethanol / 1 h / 20 °C 3: toluene-4-sulfonic acid / toluene / 0.33 h / 80 °C / |Microwave irradiation 4: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol; water / 80 °C 5: hydrogen fluoride; pyridine / tetrahydrofuran / 5 h / 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 35 p. 5782 - 5786
151884-07-0
→
反应条件
81267-65-4
脑益嗪
反应条件
1: sodium hydroxide / water / 4 h / 0 °C 2: copper(ll) bromide / ethyl acetate; chloroform; methanol / 4 h / 70 °C 3: 1H-imidazole / dichloromethane / 1.25 h / 20 °C 4: sodium tetrahydroborate / ethanol / 1 h / 20 °C 5: toluene-4-sulfonic acid / toluene / 0.33 h / 80 °C / |Microwave irradiation 6: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol; water / 80 °C 7: hydrogen fluoride; pyridine / tetrahydrofuran / 5 h / 20 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 35 p. 5782 - 5786
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