反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / 0 °C 1.2: 0.25 h / 0 °C 2.1: hydrogen; palladium 10 on activated carbon / methanol; ethyl acetate; acetic acid / 3 h / 20 °C 3.1: hydrogenchloride / methanol; water / 6 h / 30 °C 4.1: Jone's reagent / acetone; dichloromethane / 0.5 h / 0 °C 5.1: potassium hydroxide; water / methanol / 16 h / 30 °C 6.1: perchloric acid / water / 1 h / 20 °C 7.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; trifluoroacetic acid / dimethyl sulfoxide / 40 h / 40 °C 8.1: water; sodium hydroxide / 0.5 h View Scheme
参考文献
Ogawa, Shoujiro; Zhou, Biao; Kimoto, Yusuke; Omura, Kaoru; Kobayashi, Akiko; Higashi, Tatsuya; Mitamura, Kuniko; Ikegawa, Shigeo; Hagey, Lee R.; Hofmann, Alan F.; Iida, Takashi
Steroids, 2013 , vol. 78, # 9 p. 927 - 937