5'-O-[双(4-甲氧基苯基)苯基甲基]-2'-O-[(叔丁基)二甲基硅基]-N-(2-甲基-1-氧代丙基)鸟苷合成路线 （共 10 条）
反应条件
pyridinium trifluoroacetate in nitromethane T=20°C; 5 h;
参考文献
Zhang, Zhaoying; Gaffney, Barbara L.; Jones, Roger A.
Journal of the American Chemical Society, 2004 , vol. 126, # 51 p. 16700 - 16701
反应条件
N-ethyl-N,N-diisopropylamine 0.5 h; Ionic liquidball miling;
参考文献
Hardacre, Christopher; Huang, Haifeng; James, Stuart L.; Migaud, Marie E.; Norman, Sarah E.; Pitner, William R.
Chemical Communications, 2011 , vol. 47, # 20 p. 5846 - 5848
反应条件
in dichloromethane
T=20°C;
参考文献
Wexselblatt, Ezequiel; Katzhendler, Jehoshua; Saleem-Batcha, Raspudin; Hansen, Guido; Hilgenfeld, Rolf; Glaser, Gad; Vidavski, Roee R.
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 12 p. 4485 - 4497
反应条件
(2R,4S)-3-((R)-cyclopentyl(1-methyl-1H-imidazol-2-yl)methyl)-4-isopropyl-2-methoxyoxazolidine; N,N-diisopropylethylamine hydrochloride; N-ethyl-N,N-diisopropylamine in tetrahydrofuran
T=20°C; 48 h; Inert atmosphere;
参考文献
Blaisdell, Thomas P.; Lee, Sunggi; Kasaplar, Pinar; Sun, Xixi; Tan, Kian L.
Organic Letters, 2013 , vol. 15, # 18 p. 4710 - 4713
参考文献
Serebryany; Beigelman
Nucleosides, nucleotides and nucleic acids, 2003 , vol. 22, # 5-8 p. 1007 - 1009
反应条件
1: imidazole / dimethylformamide / 0 °C
2: imidazole / dimethylformamide / 60 °C
3: 96 percent / pyridine / CH2Cl2
4: HF; pyridine / CH2Cl2 / 0 °C
5: 90 percent / pyridine / 0 °C
View Scheme
参考文献
Serebryany; Beigelman
Nucleosides, nucleotides and nucleic acids, 2003 , vol. 22, # 5-8 p. 1007 - 1009
反应条件
1: imidazole / dimethylformamide / 60 °C
2: 96 percent / pyridine / CH2Cl2
3: HF; pyridine / CH2Cl2 / 0 °C
4: 90 percent / pyridine / 0 °C
View Scheme
参考文献
Serebryany; Beigelman
Nucleosides, nucleotides and nucleic acids, 2003 , vol. 22, # 5-8 p. 1007 - 1009
反应条件
1: 96 percent / pyridine / CH2Cl2
2: HF; pyridine / CH2Cl2 / 0 °C
3: 90 percent / pyridine / 0 °C
View Scheme
参考文献
Serebryany; Beigelman
Nucleosides, nucleotides and nucleic acids, 2003 , vol. 22, # 5-8 p. 1007 - 1009
反应条件
1: HF; pyridine / CH2Cl2 / 0 °C
2: 90 percent / pyridine / 0 °C
View Scheme
参考文献
Serebryany; Beigelman
Nucleosides, nucleotides and nucleic acids, 2003 , vol. 22, # 5-8 p. 1007 - 1009
反应条件
1: pyridine / 5 h / 20 °C
2: 1H-imidazole / dichloromethane; toluene / Inert atmosphere
View Scheme
参考文献
Glaser, Gad; Katzhendler, Jehoshua; Hilgenfeld, Rolf; Vidavski, Roee; Wexselblatt, Ezequiel; Prez-Menahemov, Tamar; Kaspy, Ilana
Patent: US2011/86813 A1, 2011 ;
