3-(4-氯-苯基)-异噁唑-5-羧酸乙酯合成路线 （共 9 条）
反应条件
hydroxylamine hydrochloride; potassium carbonate in ethanol Reflux;
参考文献
Dawood, Kamal M.; Abdel-Gawad, Hassan; Mohamed, Hanan A.; Badria, Farid A.
Medicinal Chemistry Research, 2011 , vol. 20, # 7 p. 912 - 919
反应条件
sodium hydrogencarbonate in ethanol; water
反应条件
trifluoroacetic acid; sodium nitrite T=20°C;
参考文献
Kadzhaeva; Trofimova; Fedotov; Potekhin; Gazzaeva; Mochalov; Zefirov
Chemistry of Heterocyclic Compounds, 2009 , vol. 45, # 5 p. 595 - 605
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / 0 °C / Inert atmosphere 1.2: 3 h / 20 °C / Inert atmosphere 2.1: hydroxylamine hydrochloride / ethanol / 6 h / Reflux View Scheme
参考文献
European Journal of Pharmaceutical Sciences, , vol. 42, # 3 p. 180 - 191
反应条件
triethylamine in tetrahydrofuran
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 2 p. 302 - 306
反应条件
trifluoroacetic acid; sodium nitrite T=20°C;
参考文献
Chemistry of Heterocyclic Compounds, , vol. 45, # 5 p. 595 - 605
反应条件
sodium tetrahydroborate in tetrahydrofuran; ethanol T=0°C; 4 h;
参考文献
Akbarzadeh, Tahmineh; Rafinejad, Ali; Mollaghasem, Javad Malekian; Safavi, Maliheh; Fallah-Tafti, Asal; Pordeli, Mahboobeh; Ardestani, Sussan Kabudanian; Shafiee, Abbas; Foroumadi, Alireza
Archiv der Pharmazie, 2012 , vol. 345, # 5 p. 386 - 392
反应条件
1: sodium tetrahydroborate / ethanol / 3 h / 20 °C / Cooling with ice 2: manganese(IV) oxide / chloroform / 24 h / 20 °C View Scheme
参考文献
Archiv der Pharmazie, , vol. 345, # 5 p. 386 - 392
反应条件
hydrazine hydrate in ethanol
4 h; Reflux;
参考文献
Dawood, Kamal M.; Abdel-Gawad, Hassan; Mohamed, Hanan A.; Badria, Farid A.
Medicinal Chemistry Research, 2011 , vol. 20, # 7 p. 912 - 919
