1-甲基-1-噻吩-2-基-乙胺合成路线 （共 3 条）
反应条件
1: methyllithium With cerium(III) chloride in tetrahydrofuran
T=-78°C; 1 h;
2: thiophene-2-carbonitrile in tetrahydrofuran
T=-78°C; 4.5 h;
参考文献
Schering Corporation and Pharmacopeia, Inc.
Patent: US2004/147559 A1, 2004 ;
Location in patent: Page 135 ;
US 20040147559 A1
反应条件
cerium(III) chloride heptahydrate in tetrahydrofuran
T=-78 - 20°C; 7.5 h;
参考文献
SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC.
Patent: WO2005/68460 A1, 2005 ;
Location in patent: Page/Page column 222 ;
WO 2005/068460 A1
反应条件
1: in tetrahydrofuran; diethyl ether
T=100°C; Double Grignard addition; 0.166667 h; Microwave irradiation;
2: With titanium(IV) isopropylate in tetrahydrofuran; diethyl ether
T=50°C; Double Grignard addition; 1 h; Microwave irradiation;
参考文献
Wang, Ruifang; Gregg, Brian T.; Zhang, Wei; Golden, Kathryn C.; Quinn, John F.; Cui, Peng; Tymoshenko, Dmytro O.
Tetrahedron Letters, 2009 , vol. 50, # 50 p. 7070 - 7073
