(三氟甲基)三甲基硅烷合成路线 （共 455 条）
反应条件
tetrabutyl ammonium fluoride in toluene T=-78 - 20°C;
参考文献
3-DIMENSIONAL PHARMACEUTICALS, INC.
Patent: WO2003/99805 A1, 2003 ;
Location in patent: Page 118 ;
反应条件
1: (trifluoromethyl)-trimethylsilane With copper(I) isothiocyanate; caesium carbonate in acetonitrile T=20°C; 0.166667 h; Inert atmosphere; 2: 2-benzoylbenzenediazonium tetrafluoroborate in acetonitrile T=20°C; Sandmeyer Reaction; 16 h; Inert atmosphere;
参考文献
Danoun, Gregory; Bayarmagnai, Bilguun; Gruenberg, Matthias F.; Goossen, Lukas J.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 31 p. 7972 - 7975
Angew. Chem., 2013 , vol. 125, # 31 p. 8130 - 8133
反应条件
potassium fluoride; copper(l) iodide in 1-methyl-pyrrolidin-2-one T=50°C; 6 h;
参考文献
Cottet, Fabrice; Marull, Marc; Mongin, Florence; Espinosa, David; Schlosser, Manfred
Synthesis, 2004 , # 10 p. 1619 - 1624
反应条件
1: C13H20N4O2 With methyl iodide T=110°C; Inert atmosphere; 2: (trifluoromethyl)-trimethylsilane With potassium fluoride; copper(l) iodide in 1-methyl-pyrrolidin-2-one T=60°C; 16 h; Inert atmosphere;
参考文献
Hafner, Andreas; Braese, Stefan
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 5 p. 996 - 1000
反应条件
potassium fluoride; copper(l) iodide in 1-methyl-pyrrolidin-2-one T=25°C;
参考文献
Cottet, Fabrice; Marull, Marc; Lefebvre, Olivier; Schlosser, Manfred
European Journal of Organic Chemistry, 2003 , # 8 p. 1559 - 1568
反应条件
1: With silver fluoride in N,N-dimethyl-formamide T=20°C; 20 h; 2: With copper in N,N-dimethyl-formamide 4 h; 3: With copper(I) bromide in N,N-dimethyl-formamide
参考文献
Kremlev, Mikhail M.; Mushta, Aleksej I.; Tyrra, Wieland; Yagupolskii, Yurii L.; Naumann, Dieter; Moeller, Angela
Journal of Fluorine Chemistry, 2012 , vol. 133, p. 67 - 71
反应条件
potassium fluoride; copper(l) iodide in 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide T=25°C; 6 h;
参考文献
European Journal of Organic Chemistry, , # 2 p. 327 - 330
反应条件
[Pd(η3-1-Ph-allyl)(μ-Cl)]2; cyclohexyl BrettPhos; sodium lauryl sulfate; cesium fluoride in toluene T=110°C; 12 h; Inert atmosphere;
参考文献
Samant, Bhupesh S.; Kabalka, George W.
Chemical Communications, 2011 , vol. 47, # 25 p. 7236 - 7238
反应条件
sulfur; potassium fluoride; o-di-fluorobenzene T=20°C; 0.5 h; Air;
参考文献
Chen, Chao; Chu, Lingling; Qing, Feng-Ling
Journal of the American Chemical Society, 2012 , vol. 134, # 30 p. 12454 - 12457
反应条件
sodium tetrahydroborate in diethylene glycol dimethyl ether T=20°C; Inert atmosphere;
参考文献
Fier, Patrick S.; Hartwig, John F.
Journal of the American Chemical Society, 2012 , vol. 134, # 12 p. 5524 - 5527
