(三氟甲基)三甲基硅烷合成路线 （共 455 条）
反应条件
1: (trifluoromethyl)-trimethylsilane With 1,10-phenanthroline; potassium tert-butylate; copper(l) chloride in N,N-dimethyl-formamide
T=20°C; 1 h; Inert atmosphere;
2: (4S,5R)-5-(3,5-diiodophenyl)-4-methyloxazolidin-2-one in N,N-dimethyl-formamide
T=50°C; 18 h; Inert atmosphere;
参考文献
Ogawa, Takanori; Kumagai, Naoya; Shibasaki, Masakatsu
Angewandte Chemie - International Edition, 2013 , vol. 52, # 24 p. 6196 - 6201
Angew. Chem., 2013 , vol. 125, # 24 p. 6316 - 6321
反应条件
1: With cesium fluoride in tetrahydrofuran
3 h;
2: With hydrogenchloride in tetrahydrofuran; water
1 h;
参考文献
VITAE PHARMACEUTICALS, INC.
Patent: WO2007/117560 A2, 2007 ;
Location in patent: Page/Page column 126 ;
WO 2007/117560 A2
反应条件
1: With cesium fluoride
T=20°C; 1 h;
2: With hydrogenchloride; water in ethylene glycol diethyl ether
T=20 - 120°C; 20.33 h; Microwave irradiation;
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/148832 A1, 2008 ;
Location in patent: Page/Page column 37-38 ;
WO 2008/148832 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C;
参考文献
Demir, Ayhan S.; Eymur, Serkan
Journal of Organic Chemistry, 2007 , vol. 72, # 22 p. 8527 - 8530
反应条件
[bis(acetoxy)iodo]benzene; silver fluoride in dimethyl sulfoxide
T=20°C; 20 h; ConcentrationReagent/catalystSolvent;
参考文献
Seo, Sangwon; Taylor, John B.; Greaney, Michael F.
Chemical Communications, 2013 , vol. 49, # 57 p. 6385 - 6387
反应条件
potassium fluoride; potassium phosphate; 1,10-phenanthroline; (CuOTf)2.C6H6; silver carbonate in N,N-dimethyl-formamide
T=45°C; 4 h; Inert atmosphere;
参考文献
Ye, Yingda; Lee, Shin Hee; Sanford, Melanie S.
Organic Letters, 2011 , vol. 13, # 20 p. 5464 - 5467
反应条件
potassium fluoride; silver trifluoromethanesulfonate in 1,2-dichloro-ethane
T=85°C; 24 h; Inert atmosphereDarkness;
参考文献
Ye, Yingda; Lee, Shin Hee; Sanford, Melanie S.
Organic Letters, 2011 , vol. 13, # 20 p. 5464 - 5467
反应条件
1: With cesium fluoride in tetrahydrofuran
T=23°C; 0.25 h;
2: With tetrabutyl ammonium fluoride; water; ammonium chloride in tetrahydrofuran
24 h;
参考文献
WARNER-LAMBERT COMPANY LLC; ELLSWORTH, Edmund, Lee
Patent: WO2005/26153 A1, 2005 ;
Location in patent: Page 43-44 ;
反应条件
1: With tris((S,S)-3,4-diphenylpyrrolidino)sulfonium salt in diethyl ether
T=-78°C; trifluoromethylation; 24 h;
2: With hydrogenchloride in tetrahydrofuran
T=20°C; Hydrolysis; 1 h;
参考文献
Kuroki, Yoshichika; Iseki, Katsuhiko
Tetrahedron Letters, 1999 , vol. 40, # 47 p. 8231 - 8234
反应条件
1: With cesium fluoride in tetrahydrofuran
T=20°C; Addition;
2: With hydrogenchloride in water
Hydrolysis; Further stages.;
参考文献
Prakash; Mandal; Schweizer; Petasis; Olah
Organic letters, 2000 , vol. 2, # 20 p. 3173 - 3176
