(三氟甲基)三甲基硅烷合成路线 （共 455 条）
反应条件
potassium fluoride; cyclohexyl BrettPhos; [(allyl)PdCl]2 in tetrahydrofuran
T=110°C; 20 h;
参考文献
Cho, Eun Jin; Senecal, Todd D.; Kinzel, Tom; Zhang, Yong; Watson, Donald A.; Buchwald, Stephen L.
Science, 2010 , vol. 328, # 5986 p. 1679 - 1681
反应条件
potassium fluoride; C50H66NO5PPdS in 1,4-dioxane; toluene
T=90°C; 15 h;
参考文献
Massachusetts Institute of Technology; Bruno, Nicholas C.; Buchwald, Stephen L.
Patent: US2013/331566 A1, 2013 ;
Location in patent: Paragraph 0068 ;
反应条件
potassium fluoride in acetonitrile
1) -40 to 20 deg C, 9.5 h, 2) 20 deg C, 7 h;
参考文献
Kotun, Stefan P.; Anderson, John D. O.; DesMarteau, Darryl D.
Journal of Organic Chemistry, 1992 , vol. 57, # 4 p. 1124 - 1131
反应条件
tetramethyl-ammonium fluoride in ethylene glycol dimethyl ether
T=-60 - 20°C;
参考文献
Kirij, Nataliya V.; Yagupolskii, Yurii L.; Petukh, Nataliya V.; Tyrra, Wieland; Naumann, Dieter
Tetrahedron Letters, 2001 , vol. 42, # 46 p. 8181 - 8183
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran; pentane
48 h; Ambient temperature;
参考文献
Wiedemann, Juergen; Heiner, Thomas; Mloston, Gregorz; Prakash, G.K. Surya; Olah, George A.
Angewandte Chemie - International Edition, 1998 , vol. 37, # 6 p. 820 - 821
反应条件
1: (trifluoromethyl)-trimethylsilane With 1,10-phenanthroline; potassium tert-butylate; copper(l) chloride in N,N-dimethyl-formamide
T=20°C; 1.5 h; Inert atmosphere;
2: 4-phenyliodobenzene in N,N-dimethyl-formamide
T=50°C; 18 h; Product distribution / selectivity;
参考文献
THE BOARD OF TRUSTESS OF THE UNIVERSITY OF ILLINOIS; HARTWIG, John, F.; MORIMOTO, Hiroyuki; FIER, Patrick
Patent: WO2012/24564 A1, 2012 ;
Location in patent: Page/Page column 7; 34-36 ;
反应条件
potassium fluoride; potassium phosphate; 1,10-phenanthroline; copper (I) trifluoromethane sulfonate benzene; silver carbonate in N,N-dimethyl-formamide
T=45°C; Inert atmosphere;
参考文献
Chu, Lingling; Qing, Feng-Ling
Organic Letters, 2010 , vol. 12, # 21 p. 5060 - 5063
反应条件
1: (trifluoromethyl)-trimethylsilane With copper(I) isothiocyanate; caesium carbonate in acetonitrile
T=20°C; 0.166667 h; Inert atmosphere;
2: [1,1'-biphenyl]-4-diazonium tetrafluoroborate in acetonitrile
T=20°C; Sandmeyer Reaction; 16 h; Inert atmosphere;
参考文献
Danoun, Gregory; Bayarmagnai, Bilguun; Gruenberg, Matthias F.; Goossen, Lukas J.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 31 p. 7972 - 7975
Angew. Chem., 2013 , vol. 125, # 31 p. 8130 - 8133
反应条件
tris(dimethylamino)-sulphonium difluorotrimethylsilicate in tetrahydrofuran
T=20°C; Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Bardin, V. V.; Kolomeitsev, A. A.; Furin, G. G.; Yagupol'skii, Yu. L.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990 , vol. 39, # 7.2 p. 1539
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990 , # 7 p. 1693 - 1694
反应条件
[bis(acetoxy)iodo]benzene; tri-n-butyl-tin hydride; sodium acetate; silver nitrate in 1-methyl-pyrrolidin-2-one
T=20°C; 6 h; Inert atmosphere; Reagent/catalyst; Overall yield = 36 percentSpectr.;
参考文献
Wu, Xinyue; Chu, Lingling; Qing, Feng-Ling
Angewandte Chemie - International Edition, 2013 , vol. 52, # 8 p. 2198 - 2202
Angew. Chem., 2013 , vol. 125, # 8 p. 2254 - 2258,5
