(三氟甲基)三甲基硅烷合成路线 （共 455 条）
反应条件
[bis(acetoxy)iodo]benzene; sodium acetate; silver trifluoromethanesulfonate in 1-methyl-pyrrolidin-2-one
T=20°C; 6 h; Inert atmosphere; Reagent/catalyst; Overall yield = 64 percentSpectr.;
参考文献
Wu, Xinyue; Chu, Lingling; Qing, Feng-Ling
Angewandte Chemie - International Edition, 2013 , vol. 52, # 8 p. 2198 - 2202
Angew. Chem., 2013 , vol. 125, # 8 p. 2254 - 2258,5
反应条件
1: With tetrabutyl ammonium fluoride in tetrahydrofuran
T=0 - 20°C;
2: With water; ammonium chloride in tetrahydrofuran; water
0.25 h;
3: With tetrabutyl ammonium fluoride in tetrahydrofuran; water
T=20°C; 1 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2540728 A1, 2013 ;
Location in patent: Page/Page column 76 ;
反应条件
1: (trifluoromethyl)-trimethylsilane With silver fluoride in anhydrous propionitrile
T=20°C; 0.333333 h;
2: With copper in anhydrous propionitrile
4 h;
3: 4-nitrobenzyl iodide in anhydrous propionitrile
T=20°C; Heating;
参考文献
Kremlev, Mikhail M.; Mushta, Aleksej I.; Tyrra, Wieland; Yagupolskii, Yurii L.; Naumann, Dieter; Moeller, Angela
Journal of Fluorine Chemistry, 2012 , vol. 133, p. 67 - 71
反应条件
1,10-phenanthroline; di-tert-butyl peroxide; copper diacetate; sodium acetate; sodium t-butanolate in 1,2-dichloro-ethane
T=80°C; 6.03333 h; Inert atmosphereMolecular sieve;
参考文献
Chu, Lingling; Qing, Feng-Ling
Journal of the American Chemical Society, 2012 , vol. 134, # 2 p. 1298 - 1304
反应条件
tris(dimethylamino)-sulphonium difluorotrimethylsilicate in Petroleum ether
T=25°C; 0.5 h;
参考文献
Kolomeitsev; Movchun; Kondratenko; Yagupolski
Synthesis, 1990 , # 12 p. 1151 - 1152
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
参考文献
Yoshimatsu, Mitsuhiro; Kuribayashi, Masako
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 11 p. 1256 - 1257
反应条件
15-crown-5; cesium fluoride in diethyl ether
T=-18 - 20°C; 1 h;
参考文献
Tyrra, Wieland; Naumann, Dieter; Quadt, Silke; Buslei, Sigrid; Yagupolskii, Yurii L.; Kremlev, Mikhail M.
Journal of Fluorine Chemistry, 2007 , vol. 128, # 7 p. 813 - 817
反应条件
potassium fluoride; 3,4,7,8-tetra-methyl-1,10-phenanthroline; 2C7H7O3S(1-)*Cu(2+)*C6H6; para-toluenesulphonic acid silver salt; silver fluoride in N,N-dimethyl-formamide
T=50°C; 24 h; GloveboxInert atmosphere; Reagent/catalyst;
参考文献
Xu, Jun; Xiao, Bin; Xie, Chuan-Qi; Luo, Dong-Fen; Liu, Lei; Fu, Yao
Angewandte Chemie - International Edition, 2012 , vol. 51, # 50 p. 12551 - 12554
Angew. Chem., 2012 , vol. 124, # 50 p. 12719 - 12722,4
反应条件
1: With tetramethyl-ammonium fluoride in tetrahydrofuran
T=0 - 20°C; 1 h;
2: With water; citric acid in tetrahydrofuran
1 h;
参考文献
MERCK and CO., INC.
Patent: WO2009/54941 A1, 2009 ;
Location in patent: Page/Page column 63 ;
WO 2009/054941 A1
反应条件
potassium fluoride; silver trifluoromethanesulfonate in 1,2-dichloro-ethane
T=85°C; 24 h; Inert atmosphereDarkness;
参考文献
Ye, Yingda; Lee, Shin Hee; Sanford, Melanie S.
Organic Letters, 2011 , vol. 13, # 20 p. 5464 - 5467
