(三氟甲基)三甲基硅烷合成路线 （共 455 条）
反应条件
1: C13H21N3O With methyl iodide T=110°C; Inert atmosphere; 2: (trifluoromethyl)-trimethylsilane With potassium fluoride; copper(l) iodide in 1-methyl-pyrrolidin-2-one T=60°C; 16 h; Inert atmosphere;
参考文献
Hafner, Andreas; Braese, Stefan
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 5 p. 996 - 1000
反应条件
1: (trifluoromethyl)-trimethylsilane With copper(I) isothiocyanate; caesium carbonate in acetonitrile T=20°C; 0.166667 h; Inert atmosphere; 2: ortho-methoxybenzenediazonium tetrafluoroborate in acetonitrile T=20°C; Sandmeyer Reaction; 16 h; Inert atmosphere;
参考文献
Danoun, Gregory; Bayarmagnai, Bilguun; Gruenberg, Matthias F.; Goossen, Lukas J.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 31 p. 7972 - 7975
Angew. Chem., 2013 , vol. 125, # 31 p. 8130 - 8133
反应条件
1: (trifluoromethyl)-trimethylsilane With copper(I) isothiocyanate; caesium carbonate in acetonitrile T=20°C; 0.166667 h; Inert atmosphere; 2: quinoline-8-diazonium tetrafluoroborate in acetonitrile T=20°C; Sandmeyer Reaction; 16 h; Inert atmosphere;
参考文献
Danoun, Gregory; Bayarmagnai, Bilguun; Gruenberg, Matthias F.; Goossen, Lukas J.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 31 p. 7972 - 7975
Angew. Chem., 2013 , vol. 125, # 31 p. 8130 - 8133
反应条件
potassium fluoride; C54H70NO5PPdS in 1,4-dioxane; toluene T=90°C; 15 h;
参考文献
Massachusetts Institute of Technology; Bruno, Nicholas C.; Buchwald, Stephen L.
Patent: US2013/331566 A1, 2013 ;
Location in patent: Paragraph 0068 ;
反应条件
copper(l) iodide; silver fluoride; sodium t-butanolate; N-methyl-2-(methylamino)ethylamine in 1-methyl-pyrrolidin-2-one T=20 - 90°C; 5.5 h; Inert atmosphere;
参考文献
Weng, Zhiqiang; Lee, Richmond; Jia, Weiguo; Yuan, Yaofeng; Wang, Wenfeng; Feng, Xue; Huang, Kuo-Wei
Organometallics, 2011 , vol. 30, # 11 p. 3229 - 3232
反应条件
1: (trifluoromethyl)-trimethylsilane With copper(I) isothiocyanate; caesium carbonate in acetonitrile T=20°C; 0.166667 h; Inert atmosphere; 2: cyano derivative of benzenediazonium tetrafluoroborate in acetonitrile T=20°C; Sandmeyer Reaction; 16 h; Inert atmosphere;
参考文献
Danoun, Gregory; Bayarmagnai, Bilguun; Gruenberg, Matthias F.; Goossen, Lukas J.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 31 p. 7972 - 7975
Angew. Chem., 2013 , vol. 125, # 31 p. 8130 - 8133
反应条件
potassium fluoride in N,N-dimethyl acetamide T=50°C; Title compound not separated from byproducts;
参考文献
Adams, Dave J.; Clark, James H.; Hansen, Liv B.; Sanders, Victoria C.; Tavener, Stewart J.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 18 p. 3081 - 3085
反应条件
1: (trifluoromethyl)-trimethylsilane With potassium fluoride; copper(l) iodide in tetrahydrofuran; N,N-dimethyl-formamide T=20 - 50°C; 21 h; 2: 3-iodo-2,6-dichloropyridine in tetrahydrofuran; N,N-dimethyl-formamide T=50°C;
参考文献
R-tech Ueno, Ltd.
Patent: WO2009/145360 A1, 2009 ;
Location in patent: Page/Page column 111-112 ;
WO 2009/145360 A1
反应条件
ATPH; potassium tert-butylate in n-heptane; dichloromethane T=-78 - 20°C; 19 h;
参考文献
Sevenard, Dmitri V.; Sosnovskikh, Vyacheslav Ya.; Kolomeitsev, Alexander A.; Koenigsmann, Martin H.; Roeschenthaler, Gerd-Volker
Tetrahedron Letters, 2003 , vol. 44, # 41 p. 7623 - 7627
反应条件
hydrogenchloride; tetrabutyl ammonium fluoride 1) THF, 0 deg C - rt; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Prakash, G. K. Surya; Krishnamurti, Ramesh; Olah, George A.
Journal of the American Chemical Society, 1989 , vol. 111, # 1 p. 393 - 395
