(11aS)-7-甲氧基-8-羟基-2,3,5,11ab-四氢-1H-吡咯并[2,1-c][1,4]苯并二氮杂卓-5-酮合成路线 （共 41 条）
反应条件
cyclohexa-1,4-diene; palladium on activated charcoal in ethanol
T=20°C; 2.5 h;
参考文献
Kamal, Ahmed; Reddy, K. Laxma; Devaiah; Shankaraiah
Synlett, 2004 , # 14 p. 2533 - 2536
反应条件
4-methyl-morpholine; [polymer-NMe3]+[RuO4]- in dichloromethane
T=20°C; 9 h;
参考文献
Kamal, Ahmed; Devaiah; Laxma Reddy; Shankaraiah
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 1-2 p. 249 - 254
反应条件
calcium carbonate; mercury dichloride in water; acetonitrile
2.5 h; Ambient temperature;
参考文献
Bose, D. Subhas; Jones, Gary B.; Thurston, David E.
Tetrahedron, 1992 , vol. 48, # 4 p. 751 - 758
反应条件
aluminium trifluoromethanesulphonate; sodium iodide in acetonitrile
T=20°C; 0.75 h; chemoselective reaction;
参考文献
Kamal, Ahmed; Markandeya, Nagula; Shankaraiah, Nagula; Ratna Reddy; Prabhakar; Sanjeeva Reddy; Eberlin, Marcos N.; Santos, Leonardo Silva
Chemistry - A European Journal, 2009 , vol. 15, # 29 p. 7215 - 7224
反应条件
1: 55 percent / DIBAL-H / CH2Cl2; hexane / 0.5 h / -78 °C
2: Me2NNH2, FeCl3*6H2O / 70 °C
3: 50 percent / SiO2 / CHCl3; methanol
View Scheme
参考文献
Kamal, Ahmed; Reddy, B. S. Nararyan; Reddy, B. S. Praveen
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 14 p. 1825 - 1828
反应条件
samarium diiodide in tetrahydrofuran
T=20°C; 2 h;
参考文献
Kamal; Laxman; Reddy
Tetrahedron Letters, 2000 , vol. 41, # 44 p. 8631 - 8634
反应条件
2: 55 percent / DIBAL-H / CH2Cl2; hexane / 0.5 h / -78 °C
3: Me2NNH2, FeCl3*6H2O / 70 °C
4: 50 percent / SiO2 / CHCl3; methanol
View Scheme
参考文献
Kamal, Ahmed; Reddy, B. S. Nararyan; Reddy, B. S. Praveen
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 14 p. 1825 - 1828
反应条件
1: (COCl)2 / dimethylformamide
2: K2CO3
3: SnCl2
4: 81 percent / pyridine / CH2Cl2 / 0.17 h / 0 °C
5: 71 percent / Dess-Martin periodinane / CH2Cl2 / 0.5 h / 20 °C
6: 88 percent / Pd(PPh3)4; pyrrolidine; PPh3 / CH2Cl2 / 0.17 h / 20 °C
7: 28 percent / 1,4-cyclohexadiene / Pd/C / ethanol / 4 h / 20 °C
View Scheme
参考文献
Tercel, Moana; Stribbling, Stephen M.; Sheppard, Hilary; Siim, Bronwyn G.; Wu, Kent; Pullen, Susan M.; Botting, K. Jane; Wilson, William R.; Denny, William A.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2132 - 2151
反应条件
1: polymer-supported cyclohexylcarbodiimide / CH2Cl2 / 20 °C
2: N-methylmorpholine / [polymer-NMe3]+[RuO4]- / CH2Cl2 / 20 °C
3: 80 percent / H2 / Pd/C / ethanol / 6 h / 20 °C / 1140 Torr
4: 70 percent / N-methylmorpholine / [polymer-NMe3]+[RuO4]- / CH2Cl2 / 9 h / 20 °C
View Scheme
参考文献
Kamal, Ahmed; Devaiah; Laxma Reddy; Shankaraiah
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 1-2 p. 249 - 254
反应条件
chloro-trimethyl-silane; sodium iodide in acetonitrile
T=20°C; Cyclization; 0.75 h;
参考文献
Kamal, Ahmed; Laxman; Venugopal Rao
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 20 p. 2311 - 2313
