(11aS)-7-甲氧基-8-羟基-2,3,5,11ab-四氢-1H-吡咯并[2,1-c][1,4]苯并二氮杂卓-5-酮合成路线 （共 41 条）
反应条件
1: 60 percent / NMO; TPAP / acetonitrile / 1.5 h / 20 °C
2: 90 percent / 1,4-cyclohexadiene / Pd/C / ethanol / 2.5 h / 20 °C
View Scheme
参考文献
Correa, Arkaitz; Tellitu, Imanol; Dominguez, Esther; Moreno, Isabel; SanMartin, Raul
Journal of Organic Chemistry, 2005 , vol. 70, # 6 p. 2256 - 2264
反应条件
1: 91 percent / EDC*HCl; HOBt; Et3N / CH2Cl2 / 0 - 20 °C
2: 67 percent / phenyliodine(III) bis(trifluoroacetate) / CH2Cl2 / 20 °C
3: 82 percent / Mo(CO)6 / acetonitrile; H2O / Heating
4: 70 percent / NaBH4; TFA / various solvent(s) / Heating
5: 60 percent / NMO; TPAP / acetonitrile / 1.5 h / 20 °C
6: 90 percent / 1,4-cyclohexadiene / Pd/C / ethanol / 2.5 h / 20 °C
View Scheme
参考文献
Correa, Arkaitz; Tellitu, Imanol; Dominguez, Esther; Moreno, Isabel; SanMartin, Raul
Journal of Organic Chemistry, 2005 , vol. 70, # 6 p. 2256 - 2264
反应条件
1: 96 percent / LiOH*H2O / tetrahydrofuran; H2O / 20 °C
2: 91 percent / EDC*HCl; HOBt; Et3N / CH2Cl2 / 0 - 20 °C
3: 67 percent / phenyliodine(III) bis(trifluoroacetate) / CH2Cl2 / 20 °C
4: 82 percent / Mo(CO)6 / acetonitrile; H2O / Heating
5: 70 percent / NaBH4; TFA / various solvent(s) / Heating
6: 60 percent / NMO; TPAP / acetonitrile / 1.5 h / 20 °C
7: 90 percent / 1,4-cyclohexadiene / Pd/C / ethanol / 2.5 h / 20 °C
View Scheme
参考文献
Correa, Arkaitz; Tellitu, Imanol; Dominguez, Esther; Moreno, Isabel; SanMartin, Raul
Journal of Organic Chemistry, 2005 , vol. 70, # 6 p. 2256 - 2264
反应条件
1: 67 percent / phenyliodine(III) bis(trifluoroacetate) / CH2Cl2 / 20 °C
2: 82 percent / Mo(CO)6 / acetonitrile; H2O / Heating
3: 70 percent / NaBH4; TFA / various solvent(s) / Heating
4: 60 percent / NMO; TPAP / acetonitrile / 1.5 h / 20 °C
5: 90 percent / 1,4-cyclohexadiene / Pd/C / ethanol / 2.5 h / 20 °C
View Scheme
参考文献
Correa, Arkaitz; Tellitu, Imanol; Dominguez, Esther; Moreno, Isabel; SanMartin, Raul
Journal of Organic Chemistry, 2005 , vol. 70, # 6 p. 2256 - 2264
反应条件
1: 82 percent / Mo(CO)6 / acetonitrile; H2O / Heating
2: 70 percent / NaBH4; TFA / various solvent(s) / Heating
3: 60 percent / NMO; TPAP / acetonitrile / 1.5 h / 20 °C
4: 90 percent / 1,4-cyclohexadiene / Pd/C / ethanol / 2.5 h / 20 °C
View Scheme
参考文献
Correa, Arkaitz; Tellitu, Imanol; Dominguez, Esther; Moreno, Isabel; SanMartin, Raul
Journal of Organic Chemistry, 2005 , vol. 70, # 6 p. 2256 - 2264
反应条件
1: 50 percent / LiBH4 / tetrahydrofuran / 8 h / -10 °C
2: 90 percent / 1,4-cyclohexadiene / Pd/C / ethanol / 2.5 h / 20 °C
View Scheme
参考文献
Hu; Wang; Lin; Hsu
Journal of Organic Chemistry, 2001 , vol. 66, # 8 p. 2881 - 2883
反应条件
Amberlite IR-120(H+) resin in water; acetonitrile
4 h; Ambient temperature;
参考文献
Bose, D. Subhas; Jones, Gary B.; Thurston, David E.
Tetrahedron, 1992 , vol. 48, # 4 p. 751 - 758
反应条件
1: 95 percent / 6-(methylsulfinyl)hexanoylmethyl-polystyrene; oxalyl chloride; Et3N / CH2Cl2 / -50 - 20 °C
2: 96 percent / triphenylphosphine-polystyrene / CH2Cl2 / 4 h / 20 °C
3: 91 percent / 1,4-cyclohexadiene / Pd/C / ethanol / 2.5 h / 20 °C
View Scheme
参考文献
Kamal, Ahmed; Reddy, K. Laxma; Devaiah; Shankaraiah
Synlett, 2004 , # 14 p. 2533 - 2536
反应条件
1: 95 percent / borohydride exchange resin / methanol / Heating
2: 98 percent / N-cyclohexylcarbodiimide-N'-methylpolystyrene / CH2Cl2 / 12 h / 20 °C
3: 95 percent / 6-(methylsulfinyl)hexanoylmethyl-polystyrene; oxalyl chloride; Et3N / CH2Cl2 / -50 - 20 °C
4: 96 percent / triphenylphosphine-polystyrene / CH2Cl2 / 4 h / 20 °C
5: 91 percent / 1,4-cyclohexadiene / Pd/C / ethanol / 2.5 h / 20 °C
View Scheme
参考文献
Kamal, Ahmed; Reddy, K. Laxma; Devaiah; Shankaraiah
Synlett, 2004 , # 14 p. 2533 - 2536
反应条件
1: 93 percent / Dowex 50x resin / CH2Cl2 / 16 h / Ambient temperature
2: 52 percent / H2 / 10percent Pd-C / methanol / 0.33 h / 760 Torr / Ambient temperature
3: 47 percent / Amberlite IR-120(H+) resin / acetonitrile; H2O / 4 h / Ambient temperature
View Scheme
参考文献
Bose, D. Subhas; Jones, Gary B.; Thurston, David E.
Tetrahedron, 1992 , vol. 48, # 4 p. 751 - 758
