(11aS)-7-甲氧基-8-羟基-2,3,5,11ab-四氢-1H-吡咯并[2,1-c][1,4]苯并二氮杂卓-5-酮合成路线 （共 41 条）
反应条件
1: 43 percent / DIBAL / toluene / 0.75 h / -78 °C
2: 93 percent / Dowex 50x resin / CH2Cl2 / 16 h / Ambient temperature
3: 52 percent / H2 / 10percent Pd-C / methanol / 0.33 h / 760 Torr / Ambient temperature
4: 47 percent / Amberlite IR-120(H+) resin / acetonitrile; H2O / 4 h / Ambient temperature
View Scheme
参考文献
Bose, D. Subhas; Jones, Gary B.; Thurston, David E.
Tetrahedron, 1992 , vol. 48, # 4 p. 751 - 758
反应条件
1: 52 percent / H2 / 10percent Pd-C / methanol / 0.33 h / 760 Torr / Ambient temperature
2: 47 percent / Amberlite IR-120(H+) resin / acetonitrile; H2O / 4 h / Ambient temperature
View Scheme
参考文献
Bose, D. Subhas; Jones, Gary B.; Thurston, David E.
Tetrahedron, 1992 , vol. 48, # 4 p. 751 - 758
反应条件
1: 76 percent / NaOH / tetrahydrofuran; H2O / 48 h / Heating
2: 83 percent / SnCl4, HNO3 / CH2Cl2 / 0.08 h / -25 °C
3: 1.) oxalyl chloride, DMF 2.) Et3N / 1. THF, r. t., 3h 2. THF, H2O, r. t., 1.5h
4: 75 percent / SnCl2*H2O / methanol / 0.67 h / Heating
5: 68 percent / HgCl2, CaCO3 / acetonitrile; H2O / 24 h / Ambient temperature
6: 89 percent / 1,4-cyclohexadiene / Pd-C / ethanol / 3 h / 20 °C
View Scheme
参考文献
Thurston; Murty; Langley; Jones
Synthesis, 1990 , # 1 p. 81 - 84
反应条件
1: 1.) oxalyl chloride, DMF 2.) Et3N / 1. THF, r. t., 3h 2. THF, H2O, r. t., 1.5h
2: 75 percent / SnCl2*H2O / methanol / 0.67 h / Heating
3: 68 percent / HgCl2, CaCO3 / acetonitrile; H2O / 24 h / Ambient temperature
4: 89 percent / 1,4-cyclohexadiene / Pd-C / ethanol / 3 h / 20 °C
View Scheme
参考文献
Thurston; Murty; Langley; Jones
Synthesis, 1990 , # 1 p. 81 - 84
反应条件
1: 68 percent / HgCl2, CaCO3 / acetonitrile; H2O / 24 h / Ambient temperature
2: 89 percent / 1,4-cyclohexadiene / Pd-C / ethanol / 3 h / 20 °C
View Scheme
参考文献
Thurston; Murty; Langley; Jones
Synthesis, 1990 , # 1 p. 81 - 84
反应条件
1: 75 percent / SnCl2*H2O / methanol / 0.67 h / Heating
2: 68 percent / HgCl2, CaCO3 / acetonitrile; H2O / 24 h / Ambient temperature
3: 89 percent / 1,4-cyclohexadiene / Pd-C / ethanol / 3 h / 20 °C
View Scheme
参考文献
Thurston; Murty; Langley; Jones
Synthesis, 1990 , # 1 p. 81 - 84
反应条件
1: DIBAL-H / CH2Cl2 / 0.75 h / -78 °C
2: FeCl3; NaI / acetonitrile / 0.25 h / 20 °C
View Scheme
参考文献
Kamal, Ahmed; Babu, A. Hari; Ramana, A. Venkata; Ramana, K. Venkata; Bharathi, E. Vijaya; Kumar, M. Shiva
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2621 - 2623
反应条件
1: DIBAL-H / CH2Cl2 / 0.75 h / -78 °C
2: FeSO4*7H2O; NH3 / CH2Cl2; H2O / 4 h / 20 °C
View Scheme
参考文献
Kamal; Laxman; Arifuddin
Tetrahedron Letters, 2000 , vol. 41, # 40 p. 7743 - 7746
反应条件
1: Raney nickel / ethanol / 6 h / Heating
2: 60 percent / TPAP, NMO, molecular sieves / acetonitrile / 1.5 h / Ambient temperature
View Scheme
参考文献
Kamal, Ahmed; Howard, Philip W.; Reddy, B.S. Narayan; Reddy, B.S. Praveen; Thurston, David E.
Tetrahedron, 1997 , vol. 53, # 9 p. 3223 - 3230
反应条件
1: Lawesson's reagent / toluene / 70 °C
2: Raney nickel / ethanol / 6 h / Heating
3: 60 percent / TPAP, NMO, molecular sieves / acetonitrile / 1.5 h / Ambient temperature
View Scheme
参考文献
Kamal, Ahmed; Howard, Philip W.; Reddy, B.S. Narayan; Reddy, B.S. Praveen; Thurston, David E.
Tetrahedron, 1997 , vol. 53, # 9 p. 3223 - 3230
