4-(2-甲基-1H-咪唑)苯酚合成路线 （共 4 条）
反应条件
hydrogen bromide; potassium carbonate; Copper(I)chloride in 1-methyl-pyrrolidin-2-one
参考文献
A. H. Robins Company, Incorporated
Patent: US5194446 A1, 1993 ;
反应条件
phosphoric acid
T=210 - 220°C; 4 h;
参考文献
Tashiro, Masashi; Itoh, Takashi; Fukata, Gouki
Synthesis, 1982 , # 3 p. 217 - 219
反应条件
hydrogen bromide
T=100°C; 16 h;
参考文献
Nakamura, Toshio; Sato, Masakazu; Kakinuma, Hiroyuki; Miyata, Noriyuki; Taniguchi, Kazuo; Bando, Kagumi; Koda, Ayumi; Kameo, Kazuya
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5416 - 5427
反应条件
1: 94 percent / [Cu(OH)-TMEDA]2Cl2; O2 / CH2Cl2 / 18 h / 20 °C
2: 40 percent / aq. HBr / 16 h / 100 °C
View Scheme
参考文献
Nakamura, Toshio; Sato, Masakazu; Kakinuma, Hiroyuki; Miyata, Noriyuki; Taniguchi, Kazuo; Bando, Kagumi; Koda, Ayumi; Kameo, Kazuya
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5416 - 5427
