1: N1-methyl-N1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1,3-propanediamine hydrochloride With triethylamine in dichloromethane T=25 - 30°C; 1 h; 2: (R/S)-tetrahydrofuran-2-carboxylic acid With 1,1'-carbonyldiimidazole in dichloromethane T=40 - 45°C; 3 h; Product distribution / selectivity;