6-(2-丙烯基)二氢麦角酸合成路线 （共 3 条）
反应条件
triethylamine in dichloromethane T=0 - 25°C; 20 h; Product distribution / selectivity;
参考文献
Apotex Pharmachem Inc.
Patent: US2008/275240 A1, 2008 ;
Location in patent: Page/Page column 12 ;
反应条件
1: in trifluoromethylbenzene (BTF) T=24 - 38°C; 2: With water; acetic acid in trifluoromethylbenzene (BTF) pH=5.0 - 5.5; 3: With potassium hydroxide in tert-butyl methyl ether; water pH=9.5 - 10.0;
参考文献
Resolution Chemicals Limited
Patent: US2007/197576 A1, 2007 ;
Location in patent: Page/Page column 4; 1 ;
反应条件
1: With N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=20°C; 30 h; 2: With ammonia; water in dichloromethane
参考文献
LEK Pharmaceuticals d.d.
Patent: EP1953157 A1, 2008 ;
Location in patent: Page/Page column 7 ;
