(8beta)-N-[[[3-(二甲基氨基)丙基]氨基]羰基]-N-乙基-6-(2-丙烯-1-基)-麦角灵-8-甲酰胺合成路线 (共 2 条)
反应条件
triethylamine
T=20°C; Product distribution / selectivity;
参考文献
Apotex Pharmachem Inc.
Patent: US2008/275240 A1, 2008 ;
Location in patent: Page/Page column 13 ;
反应条件
1: With sodium hydroxide in methanol; water
T=20°C;
2: With hydrogenchloride in methanol; water
参考文献
Apotex Pharmachem Inc.
Patent: US2008/275240 A1, 2008 ;
Location in patent: Page/Page column 12-13 ;