[(4-溴噻吩-2-基)甲基](甲基)胺合成路线 （共 3 条）
反应条件
1: in tetrahydrofuran; methanol
T=0 - 20°C; 16 h;
2: With methanol; sodium tetrahydroborate
T=0 - 20°C; 6 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: US2009/156642 A1, 2009 ;
Location in patent: Page/Page column 63 ;
反应条件
1: With sodium cyanoborohydride in acetonitrile
T=20°C;
2: With sodium hydroxide; water in acetonitrile
Product distribution / selectivity;
参考文献
GALDERMA RESEARCH and DEVELOPMENT, S.N.C.
Patent: WO2006/53791 A2, 2006 ;
Location in patent: Page/Page column 71-72 ;
WO 2006/053791 A2
反应条件
triethylamine in tetrahydrofuran
T=20°C; 0.5 h;
参考文献
GALDERMA RESEARCH and DEVELOPMENT, S.N.C.
Patent: WO2006/53791 A2, 2006 ;
Location in patent: Page/Page column 33-35 ;
WO 2006/053791 A2
