6-溴-7-甲氧基苯并[d][1,3]二氧代le-5-羧酸甲酯合成路线 （共 19 条）
反应条件
1: With hydrogen bromide; sodium nitrite in water
T=5°C;
2: With hydrogen bromide; copper(I) bromide
T=50 - 60°C; 0.5 h;
参考文献
Chang, Junbiao; Chen, Rongfeng; Guo, Ruiyun; Dong, Chunhong; Zhao, Kang
Helvetica Chimica Acta, 2003 , vol. 86, # 6 p. 2239 - 2246
反应条件
potassium fluoride in N,N-dimethyl-formamide
T=110°C;
参考文献
Alam, Ashraful; Takaguchi, Yutaka; Ito, Hideyuki; Yoshida, Takashi; Tsuboi, Sadao
Tetrahedron, 2005 , vol. 61, # 7 p. 1909 - 1918
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=70°C; 12 h;
参考文献
Alam, Ashraful; Takaguchi, Yutaka; Ito, Hideyuki; Yoshida, Takashi; Tsuboi, Sadao
Tetrahedron, 2005 , vol. 61, # 7 p. 1909 - 1918
反应条件
potassium carbonate in acetone
4 h; Reflux;
参考文献
Song, Chuanjun; Zhao, Peng; Hu, Zhiqiang; Shi, Shuai; Cui, Yanmei; Chang, Junbiao
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 7 p. 2297 - 2298
反应条件
sodium hydroxide in water
T=20°C; 1.5 h;
参考文献
Wu, Gang; Guo, Huan-Fang; Gao, Kun; Liu, Yi-Nan; Bastow, Kenneth F.; Morris-Natschke, Susan L.; Lee, Kuo-Hsiung; Xie, Lan
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 19 p. 5272 - 5276
反应条件
1: 62 percent / potassium carbonate / acetonitrile / 16 h / 20 °C
2: 100 percent / 1,3-dibromo-5,5-dimethylhydantoin / CHCl3 / 2 h / 20 °C
3: 99 percent / potassium carbonate / dimethylformamide / 14 h / 50 °C
4: 100 percent / Amberlyst 15E / methanol / Heating
5: 85 percent / potassium fluoride / dimethylformamide / 110 °C
View Scheme
参考文献
Alam, Ashraful; Takaguchi, Yutaka; Ito, Hideyuki; Yoshida, Takashi; Tsuboi, Sadao
Tetrahedron, 2005 , vol. 61, # 7 p. 1909 - 1918
反应条件
1: 100 percent / sulfuric acid / 6 h / Heating
2: 62 percent / potassium carbonate / acetonitrile / 16 h / 20 °C
3: 100 percent / 1,3-dibromo-5,5-dimethylhydantoin / CHCl3 / 2 h / 20 °C
4: 99 percent / potassium carbonate / dimethylformamide / 14 h / 50 °C
5: 100 percent / Amberlyst 15E / methanol / Heating
6: 85 percent / potassium fluoride / dimethylformamide / 110 °C
View Scheme
参考文献
Alam, Ashraful; Takaguchi, Yutaka; Ito, Hideyuki; Yoshida, Takashi; Tsuboi, Sadao
Tetrahedron, 2005 , vol. 61, # 7 p. 1909 - 1918
反应条件
1: 90 percent / TiCl4 / CHCl3 / 12 h / 20 °C
2: 95 percent / 1,3-dibromo-5,5-dimethylhydantoin / CHCl3 / 10 h / 20 °C
3: 95 percent / potassium carbonate / dimethylformamide / 12 h / 70 °C
View Scheme
参考文献
Alam, Ashraful; Takaguchi, Yutaka; Ito, Hideyuki; Yoshida, Takashi; Tsuboi, Sadao
Tetrahedron, 2005 , vol. 61, # 7 p. 1909 - 1918
反应条件
1: 100 percent / potassium carbonate / dimethylformamide / 12 h / 70 °C
2: 100 percent / hydrochloric acid / methanol; H2O / 2 h / 20 °C
3: 90 percent / potassium fluoride / dimethylformamide / 110 °C
4: 90 percent / TiCl4 / CHCl3 / 12 h / 20 °C
5: 95 percent / 1,3-dibromo-5,5-dimethylhydantoin / CHCl3 / 10 h / 20 °C
6: 95 percent / potassium carbonate / dimethylformamide / 12 h / 70 °C
View Scheme
参考文献
Alam, Ashraful; Takaguchi, Yutaka; Ito, Hideyuki; Yoshida, Takashi; Tsuboi, Sadao
Tetrahedron, 2005 , vol. 61, # 7 p. 1909 - 1918
反应条件
1.1: K2CO3 / acetone
2.1: 77 percent / HNO3 / 2 h / 0 - 5 °C
3.1: 34 percent / SnCl2*2H2O; aq. HCl / 0.5 h / Heating
4.1: NaNO2; aq. HBr / 0 - 5 °C
4.2: 69 percent / CuBr; aq. HBr
View Scheme
参考文献
Chang, Junbiao; Guo, Xiaohe; Cheng, Senxiang; Guo, Ruiyun; Chen, Rongfeng; Zhao, Kang
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2131 - 2136
