6-溴-7-甲氧基苯并[d][1,3]二氧代le-5-羧酸甲酯合成路线 （共 19 条）
反应条件
1.1: 77 percent / HNO3 / 2 h / 0 - 5 °C
2.1: 34 percent / SnCl2*2H2O; aq. HCl / 0.5 h / Heating
3.1: NaNO2; aq. HBr / 0 - 5 °C
3.2: 69 percent / CuBr; aq. HBr
View Scheme
参考文献
Chang, Junbiao; Guo, Xiaohe; Cheng, Senxiang; Guo, Ruiyun; Chen, Rongfeng; Zhao, Kang
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2131 - 2136
反应条件
1.1: 34 percent / SnCl2*2H2O; aq. HCl / 0.5 h / Heating
2.1: NaNO2; aq. HBr / 0 - 5 °C
2.2: 69 percent / CuBr; aq. HBr
View Scheme
参考文献
Chang, Junbiao; Guo, Xiaohe; Cheng, Senxiang; Guo, Ruiyun; Chen, Rongfeng; Zhao, Kang
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2131 - 2136
反应条件
1: 99 percent / potassium carbonate / dimethylformamide / 14 h / 50 °C
2: 100 percent / Amberlyst 15E / methanol / Heating
3: 85 percent / potassium fluoride / dimethylformamide / 110 °C
View Scheme
参考文献
Alam, Ashraful; Takaguchi, Yutaka; Ito, Hideyuki; Yoshida, Takashi; Tsuboi, Sadao
Tetrahedron, 2005 , vol. 61, # 7 p. 1909 - 1918
反应条件
1: 100 percent / Amberlyst 15E / methanol / Heating
2: 85 percent / potassium fluoride / dimethylformamide / 110 °C
View Scheme
参考文献
Alam, Ashraful; Takaguchi, Yutaka; Ito, Hideyuki; Yoshida, Takashi; Tsuboi, Sadao
Tetrahedron, 2005 , vol. 61, # 7 p. 1909 - 1918
反应条件
1: 100 percent / 1,3-dibromo-5,5-dimethylhydantoin / CHCl3 / 2 h / 20 °C
2: 99 percent / potassium carbonate / dimethylformamide / 14 h / 50 °C
3: 100 percent / Amberlyst 15E / methanol / Heating
4: 85 percent / potassium fluoride / dimethylformamide / 110 °C
View Scheme
参考文献
Alam, Ashraful; Takaguchi, Yutaka; Ito, Hideyuki; Yoshida, Takashi; Tsuboi, Sadao
Tetrahedron, 2005 , vol. 61, # 7 p. 1909 - 1918
反应条件
1: 90 percent / potassium fluoride / dimethylformamide / 110 °C
2: 90 percent / TiCl4 / CHCl3 / 12 h / 20 °C
3: 95 percent / 1,3-dibromo-5,5-dimethylhydantoin / CHCl3 / 10 h / 20 °C
4: 95 percent / potassium carbonate / dimethylformamide / 12 h / 70 °C
View Scheme
参考文献
Alam, Ashraful; Takaguchi, Yutaka; Ito, Hideyuki; Yoshida, Takashi; Tsuboi, Sadao
Tetrahedron, 2005 , vol. 61, # 7 p. 1909 - 1918
反应条件
1: 95 percent / 1,3-dibromo-5,5-dimethylhydantoin / CHCl3 / 10 h / 20 °C
2: 95 percent / potassium carbonate / dimethylformamide / 12 h / 70 °C
View Scheme
参考文献
Alam, Ashraful; Takaguchi, Yutaka; Ito, Hideyuki; Yoshida, Takashi; Tsuboi, Sadao
Tetrahedron, 2005 , vol. 61, # 7 p. 1909 - 1918
反应条件
potassium carbonate in acetone
参考文献
Li, Yanfeng; Wang, Qiang; Dong, Lihong; Guo, Xiaohe; Wang, Wei; Xie, Jingxi; Chang, Junbiao
Synthesis, 2009 , # 20 p. 3383 - 3390
反应条件
potassium hydroxide
2 h; Heating;
参考文献
Tan, Qitao; Li, Hongyan; Wen, Jiwu; Jiang, Chen; Wang, Xin; You, Tianpa
Synthetic Communications, 2005 , vol. 35, # 17 p. 2289 - 2296
