N-二苯亚甲基-甘氨酸叔丁酯合成路线 （共 23 条）
反应条件
1: With potassium hydroxide; N-anthracenylmethylcinchonium chloride in toluene T=25°C; 18 h; 2: With citric acid in tetrahydrofuran T=25°C; Title compound not separated from byproducts;
参考文献
Lygo; Crosby; Lowdon; Peterson; Wainwright
Tetrahedron, 2001 , vol. 57, # 12 p. 2403 - 2409
反应条件
1: 92 percent / aq. KOH / O-allyl-N-(9-anthracenyl)methylcinchonidium bromide / toluene / 14 h
2: 96 percent / aq. citric acid / tetrahydrofuran
3: 94 percent / triethylamine / dimethylformamide
4: 70 percent / NaBH4; LiCl / tetrahydrofuran; ethanol / 0 °C
5: 81 percent / triphenylphosphane; bromine; imidazole / CH2Cl2 / 2 h / 0 °C
View Scheme
参考文献
Siebum, Arjan H. G.; Tsang, Robert K. F.; Van Der Steen, Rob; Raap, Jan; Lugtenburg, Johan
European Journal of Organic Chemistry, 2004 , # 21 p. 4391 - 4396
反应条件
hydrogenchloride; sodium hydroxide; N1-benzylcinchonidinium chloride
1) CH2Cl2, rt, 36 h; 2) reflux, 5 h; 3) benzene, 0 deg C, 10 min, rt, overnight; Yield given. Multistep reaction;
参考文献
Torrado, Alicia; Imperiali, Barbara
Journal of Organic Chemistry, 1996 , vol. 61, # 25 p. 8940 - 8948
