5-溴-4-氯噻吩并[2,3-d]嘧啶合成路线 （共 6 条）
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran T=-78°C; 1 h; Inert atmosphere;
参考文献
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; MARUGAN, Juan, J.; ZHENG, Wei; SOUTHALL, Noel; HUANG, Wenwei; MCCOY, Joshua, G.; TITUS, Steven; PATNAIK, Samarjit
Patent: WO2012/44993 A1, 2012 ;
Location in patent: Page/Page column 44 ;
反应条件
1: bromine; sodium acetate / acetic acid / Reflux 2: acetic acid; zinc / water 3: trichlorophosphate / 0.5 h / 100 °C / Microwave irradiation View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 18 p. 5521 - 5527
反应条件
1: sulfuric acid / 0.25 h / 100 °C / Microwave irradiation 2: bromine; sodium acetate / acetic acid / Reflux 3: acetic acid; zinc / water 4: trichlorophosphate / 0.5 h / 100 °C / Microwave irradiation View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 18 p. 5521 - 5527
反应条件
1: acetic acid; zinc / water 2: trichlorophosphate / 0.5 h / 100 °C / Microwave irradiation View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 18 p. 5521 - 5527
反应条件
1: trichlorophosphate / 6 h / Reflux 2: diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere View Scheme
反应条件
1: With isopropylmagnesium chloride in tetrahydrofuran
T=0°C; 0.266667 h;
2: With iodine in tetrahydrofuran
0.333333 h;
3: With ammonium chloride in tetrahydrofuran; water
参考文献
Brewster, William Kirkland; Klittich, Carla Jean Rasmussen; Balko, Terry William; Breaux, Nneka Tuere; Erickson, William Randal; Hunter, James Edward; Lowe, Christian Thomas; Ricks, Michael John; Siddall, Thomas Lyman; Yerkes, Carla Nanette; Zhu, Yuanming
Patent: US2006/89370 A1, 2006 ;
Location in patent: Page/Page column 15 ;
