3-氧杂-9-苄基-9-氮杂双环[3.3.1]壬烷-7-酮合成路线 (共 4 条)
反应条件
hydrogenchloride; sodium acetate in water T=20°C; 72 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 24 p. 6952 - 6956
反应条件
1: bis-(2,2-diethoxy-ethyl) ether With acetic acid in water T=100°C; 2 h; 2: acetone-1,3-dicarboxylic acid; benzylamine With disodium hydrogenphosphate; citric acid in water T=25 - 28°C; 24 h; 3: With sodium hydroxide in water pH=11;
参考文献
WO2009/27820 A2, ;
Page/Page column 322-323 ;
WO 2009/027820 A2
反应条件
1: 2-(2,2-diethoxyethoxy)-1,1-dimethoxyethane; [14C]-N-Benzylamine hydrochloride With hydrogenchloride; dipotassium hydrogenphosphate; acetic acid; citric acid in water T=0 - 5°C; Mannich Reaction; 2: acetone-1,3-dicarboxylic acid in water T=20°C; Mannich Reaction; pH=4;
参考文献
WO2008/143856 A1, ;
Page/Page column 32 ;
WO 2008/143856 A1
反应条件
hydrogenchloride 6.5 h;
参考文献
WO2010/75269 A1, ;
Page/Page column 46 ;
WO 2010/075269 A1