2: 92 percent / diisopropylethylamine / CH2Cl2 / Ambient temperature 3: 95 percent / NaH / tetrahydrofuran / -30 °C 4: 87 percent / NH3 / methanol 5: 90 percent / n-Bu3N, PPh3 / Pd(OAc)2 / toluene / 48 h / 110 °C / 3800 Torr 6: 65 percent / HCl / methanol / 12 h / 50 °C 7: molecular sieve, PCC / CH2Cl2 / 2 h / Ambient temperature 8: 1.) t-BuOK / 1.) THF, 20 min; 2.) THF, room temperature, 1 h 9: 30 percent / MCPBA, NaHCO3 / not given 10: 1.) Li, ClPPh2 / 1.) THF; 2.) THF 11: 1.) NaBH4; 2.) silica gel / 1.) EtOH, 0 degC, 3 h; 2.) room temperature, 30 min, benzene View Scheme

1: 90 percent / n-Bu3N, PPh3 / Pd(OAc)2 / toluene / 48 h / 110 °C / 3800 Torr 2: 65 percent / HCl / methanol / 12 h / 50 °C 3: molecular sieve, PCC / CH2Cl2 / 2 h / Ambient temperature 4: 1.) t-BuOK / 1.) THF, 20 min; 2.) THF, room temperature, 1 h 5: 30 percent / MCPBA, NaHCO3 / not given 6: 1.) Li, ClPPh2 / 1.) THF; 2.) THF 7: 1.) NaBH4; 2.) silica gel / 1.) EtOH, 0 degC, 3 h; 2.) room temperature, 30 min, benzene View Scheme

1: 92 percent / diisopropylethylamine / CH2Cl2 / Ambient temperature 2: 95 percent / NaH / tetrahydrofuran / -30 °C 3: 87 percent / NH3 / methanol 4: 90 percent / n-Bu3N, PPh3 / Pd(OAc)2 / toluene / 48 h / 110 °C / 3800 Torr 5: 65 percent / HCl / methanol / 12 h / 50 °C 6: molecular sieve, PCC / CH2Cl2 / 2 h / Ambient temperature 7: 1.) t-BuOK / 1.) THF, 20 min; 2.) THF, room temperature, 1 h 8: 30 percent / MCPBA, NaHCO3 / not given 9: 1.) Li, ClPPh2 / 1.) THF; 2.) THF 10: 1.) NaBH4; 2.) silica gel / 1.) EtOH, 0 degC, 3 h; 2.) room temperature, 30 min, benzene View Scheme

2: 92 percent / diisopropylethylamine / CH2Cl2 / Ambient temperature 3: 95 percent / NaH / tetrahydrofuran / -30 °C 4: 87 percent / NH3 / methanol 5: 90 percent / n-Bu3N, PPh3 / Pd(OAc)2 / toluene / 48 h / 110 °C / 3800 Torr 6: 65 percent / HCl / methanol / 12 h / 50 °C 7: molecular sieve, PCC / CH2Cl2 / 2 h / Ambient temperature 8: 1.) t-BuOK / 1.) THF, 20 min; 2.) THF, room temperature, 1 h 9: 30 percent / MCPBA, NaHCO3 / not given 10: 1.) Li, ClPPh2 / 1.) THF; 2.) THF 11: 1.) NaBH4; 2.) silica gel / 1.) EtOH, 0 degC, 3 h; 2.) room temperature, 30 min, benzene View Scheme

1: 95 percent / NaH / tetrahydrofuran / -30 °C 2: 87 percent / NH3 / methanol 3: 90 percent / n-Bu3N, PPh3 / Pd(OAc)2 / toluene / 48 h / 110 °C / 3800 Torr 4: 65 percent / HCl / methanol / 12 h / 50 °C 5: molecular sieve, PCC / CH2Cl2 / 2 h / Ambient temperature 6: 1.) t-BuOK / 1.) THF, 20 min; 2.) THF, room temperature, 1 h 7: 30 percent / MCPBA, NaHCO3 / not given 8: 1.) Li, ClPPh2 / 1.) THF; 2.) THF 9: 1.) NaBH4; 2.) silica gel / 1.) EtOH, 0 degC, 3 h; 2.) room temperature, 30 min, benzene View Scheme

1: 87 percent / NH3 / methanol 2: 90 percent / n-Bu3N, PPh3 / Pd(OAc)2 / toluene / 48 h / 110 °C / 3800 Torr 3: 65 percent / HCl / methanol / 12 h / 50 °C 4: molecular sieve, PCC / CH2Cl2 / 2 h / Ambient temperature 5: 1.) t-BuOK / 1.) THF, 20 min; 2.) THF, room temperature, 1 h 6: 30 percent / MCPBA, NaHCO3 / not given 7: 1.) Li, ClPPh2 / 1.) THF; 2.) THF 8: 1.) NaBH4; 2.) silica gel / 1.) EtOH, 0 degC, 3 h; 2.) room temperature, 30 min, benzene View Scheme

3: 49 percent / n-Bu3N, PPh3 / Pd(OAc)2 / toluene / 48 h / 110 °C / 3800 Torr 4: 65 percent / HCl / methanol / 12 h / 50 °C 5: molecular sieve, PCC / CH2Cl2 / 2 h / Ambient temperature 6: 1.) t-BuOK / 1.) THF, 20 min; 2.) THF, room temperature, 1 h 7: 30 percent / MCPBA, NaHCO3 / not given 8: 1.) Li, ClPPh2 / 1.) THF; 2.) THF 9: 1.) NaBH4; 2.) silica gel / 1.) EtOH, 0 degC, 3 h; 2.) room temperature, 30 min, benzene View Scheme

1: CH2Cl2 / 1 h / 0 °C 3: 92 percent / diisopropylethylamine / CH2Cl2 / Ambient temperature 4: 95 percent / NaH / tetrahydrofuran / -30 °C 5: 87 percent / NH3 / methanol 6: 90 percent / n-Bu3N, PPh3 / Pd(OAc)2 / toluene / 48 h / 110 °C / 3800 Torr 7: 65 percent / HCl / methanol / 12 h / 50 °C 8: molecular sieve, PCC / CH2Cl2 / 2 h / Ambient temperature 9: 1.) t-BuOK / 1.) THF, 20 min; 2.) THF, room temperature, 1 h 10: 30 percent / MCPBA, NaHCO3 / not given 11: 1.) Li, ClPPh2 / 1.) THF; 2.) THF 12: 1.) NaBH4; 2.) silica gel / 1.) EtOH, 0 degC, 3 h; 2.) room temperature, 30 min, benzene View Scheme

1: 65 percent / HCl / methanol / 12 h / 50 °C 2: molecular sieve, PCC / CH2Cl2 / 2 h / Ambient temperature 3: 1.) t-BuOK / 1.) THF, 20 min; 2.) THF, room temperature, 1 h 4: 30 percent / MCPBA, NaHCO3 / not given 5: 1.) Li, ClPPh2 / 1.) THF; 2.) THF 6: 1.) NaBH4; 2.) silica gel / 1.) EtOH, 0 degC, 3 h; 2.) room temperature, 30 min, benzene View Scheme

1: molecular sieve, PCC / CH2Cl2 / 2 h / Ambient temperature 2: 1.) t-BuOK / 1.) THF, 20 min; 2.) THF, room temperature, 1 h 3: 30 percent / MCPBA, NaHCO3 / not given 4: 1.) Li, ClPPh2 / 1.) THF; 2.) THF 5: 1.) NaBH4; 2.) silica gel / 1.) EtOH, 0 degC, 3 h; 2.) room temperature, 30 min, benzene View Scheme