methanol; sodium acetate; acetic acid; palladium on activated charcoal; sodium methylate 1.) ethanol, water, heating for 17 h at 75 deg C; 2.) 20 min; Yield given. Multistep reaction;

1: 67 percent / mercuric bromide, mercuric cyanide, 4A molecular sieves / acetonitrile / 1 h / Ambient temperature 2: 1.) acetic acid, sodium acetate; 2.) methanol / 1.) 10 percent palladium-on-charcoal; 2.) 2 M sodium methoxide / 1.) ethanol, water, heating for 17 h at 75 deg C; 2.) 30 min View Scheme

acetic acid in water T=80°C; 0.5 h; Heating;

1: 76 percent / 50 percent sodium hydroxide / tetra-butylammonium hydrogen sulfate / CH2Cl2; H2O / 20 h / Heating 2: 90 percent / mercuric bromide, mercuric cyanide, 4A molecular sieves / acetonitrile / 1 h / Ambient temperature 3: 78 percent / 60 percent acetic acid / H2O / 0.5 h / 80 °C / Heating View Scheme

1: bromotrimethylsilane / CH2Cl2 / 2 h / Heating 2: 90 percent / mercuric bromide, mercuric cyanide, 4A molecular sieves / acetonitrile / 1 h / Ambient temperature 3: 78 percent / 60 percent acetic acid / H2O / 0.5 h / 80 °C / Heating View Scheme

1: 90 percent / mercuric bromide, mercuric cyanide, 4A molecular sieves / acetonitrile / 1 h / Ambient temperature 2: 78 percent / 60 percent acetic acid / H2O / 0.5 h / 80 °C / Heating View Scheme

1: 90 percent / mercuric bromide, mercuric cyanide, 4A molecular sieves / acetonitrile / 1 h / Ambient temperature 2: 78 percent / 60 percent acetic acid / H2O / 0.5 h / 80 °C / Heating View Scheme