5-溴-2-(甲硫基)-4(1氢)-嘧啶酮合成路线 (共 9 条)
反应条件
potassium hydroxide; bromine; sodium bromide in 1,4-dioxane T=70°C; 1 h;
参考文献
Gacek; Undheim
1982 , vol. 36, # 1 B p. 15 - 18
反应条件
tetrakis(triphenylphosphine) palladium(0); copper(I) bromide dimethylsulfide complex in tetrahydrofuran Liebeskind-Srogl cross-coupling; 24 h; Inert atmosphereReflux;
参考文献
Sun, Qi; Suzenet, Franck; Guillaumet, Gerald
Journal of Organic Chemistry, 2010 , vol. 75, # 10 p. 3473 - 3476
反应条件
in N,N-dimethyl-formamide T=80°C; 6 h;
参考文献
, vol. 36, # 1 B p. 15 - 18
反应条件
in ethylene glycol dimethyl ether 1.16667 h; Heating;
参考文献
, vol. 36, # 1 B p. 15 - 18
反应条件
1: POCl3 2: 91 percent / methanol / 20 h / Ambient temperature View Scheme
参考文献
Gacek; Undheim
1982 , vol. 36, # 1 B p. 15 - 18
参考文献
Gacek; Undheim
1982 , vol. 36, # 1 B p. 15 - 18
参考文献
Johnson; Joyce
Journal of the American Chemical Society, 1916 , vol. 38, p. 1564
反应条件
CaH2 in tetrahydrofuran T=0 - 20°C; 19 h; Heating / reflux;
参考文献
Pharmacia Corporation
Patent: US6653316 B1, 2003 ;
Location in patent: Page/Page column 117-118 ;
US 6653316 B1
反应条件
CaH2 in tetrahydrofuran 16 h; Heating;
参考文献
Kusturin, Carrie; Liebeskind, Lanny S.; Rahman, Hayat; Sample, Kirby; Schweitzer, Barbara; Srogl, Jiri; Neumann, William L.
Organic Letters, 2003 , vol. 5, # 23 p. 4349 - 4352