2-氯-4-三氟甲基吡啶合成路线 （共 22 条）
反应条件
thionyl chloride Reflux;
参考文献
Jiang, Biao; Xiong, Wennan; Zhang, Xiaobing; Zhang, Fangjiang
Organic Process Research and Development, 2001 , vol. 5, # 5 p. 531 - 534
反应条件
1: 73 percent / MCPBA / CH2Cl2 / 10 h / 20 °C 2: 42 percent / SOCl2 / 3 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 4 p. 475 - 477
反应条件
potassium fluoride; copper(l) iodide in 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide T=25°C; 6 h;
参考文献
Cottet, Fabrice; Schlosser, Manfred
European Journal of Organic Chemistry, 2002 , # 2 p. 327 - 330
反应条件
phosphorus pentachloride; trichlorophosphate 3 h; Heating;
参考文献
Jiang, Biao; Xiong, Wennan; Zhang, Xiaobing; Zhang, Fangjiang
Organic Process Research and Development, 2001 , vol. 5, # 5 p. 531 - 534
反应条件
in N,N-dimethyl-formamide T=80°C; 8 h; Sealed tubeInert atmosphere; regioselective reaction;
参考文献
Mormino, Michael G.; Fier, Patrick S.; Hartwig, John F.
Organic Letters, 2014 , vol. 16, # 6 p. 1744 - 1747
反应条件
1: 90 percent / O3 / CH2Cl2; methanol / 24 h / -78 °C 2: 70 percent / NH3 / methanol / 24 h / Heating 3: 73 percent / MCPBA / CH2Cl2 / 10 h / 20 °C 4: 42 percent / SOCl2 / 3 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 4 p. 475 - 477
反应条件
1: 70 percent / NH3 / methanol / 24 h / Heating 2: 73 percent / MCPBA / CH2Cl2 / 10 h / 20 °C 3: 42 percent / SOCl2 / 3 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 4 p. 475 - 477
反应条件
1: With tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; hexanes 2.5 h; Heating / reflux; 2: With hydrogenchloride in 1,4-dioxane; hexanes; water T=0°C;
参考文献
ARGENTA DISCOVERY LTD.
Patent: WO2007/31747 A1, 2007 ;
Location in patent: Page/Page column 63 ;
WO 2007/031747 A1
反应条件
1: 76 percent / NH3 / H2O / 24 h / 170 °C 2: 72 percent / H2SO4, NaNO2 / H2O / 1 h / 70 °C View Scheme
参考文献
Dunn
Journal of Fluorine Chemistry, 1999 , vol. 93, # 2 p. 153 - 157
反应条件
NiBr2(PPh3)2; tetraethylammonium iodide; zinc in tetrahydrofuran T=50°C; 48 h;
参考文献
McFarland, Sherri A.; Cheng, Karen A. W. Y.; Lee, Felix S.; Cozens, Frances L.; Schepp, Norman P.
Canadian Journal of Chemistry, 2008 , vol. 86, # 12 p. 1118 - 1125
