暂无反应条件数据

暂无反应条件数据

1: Fmoc-Gly Wang resin With piperidine in N,N-dimethyl-formamide T=20°C; 2: 2-Bromobenzoic acid With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=20°C; 2 h; 3: With tri-iso-propylsilane; trifluoroacetic acid T=20°C; 1 h;

water; sodium hydroxide in 2-methyl tetrahydrofuran T=25 - 28°C; 1 h;

1.1: sodium hydrogencarbonate / 2-methyl tetrahydrofuran; water / 0.5 h / Cooling 1.2: 3 h / 10 °C / Cooling 2.1: water; sodium hydroxide / 2-methyl tetrahydrofuran / 1 h / 25 - 28 °C View Scheme

sodium hydroxide

sodium acetate; acetic anhydride in 2-methyl tetrahydrofuran Erlenmeyer-Plochl reaction; 24 h; Reflux;

sodium acetate in acetic anhydride 3 h; Heating;