2-氨基-5-异丙基-1,3-噻唑-4-羧酸甲酯合成路线 （共 7 条）
反应条件
methanol; sodium 1.) Et2O, 0 deg C, 1 h, 2.) MeOH, reflux, 4 h; Yield given. Multistep reaction;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 159 - 164
反应条件
in methanol 6 h; Heating / reflux;
参考文献
US2005/182104 A1, ;
Page/Page column 6 ;
反应条件
1: isobutyraldehyde; dichloroacetic acid ethyl ester With sodium methylate in diethyl ether 2: methanol; thiourea Heating;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 16 p. 3732 - 3736
反应条件
sulfuric acid; copper(II) sulfate; sodium chloride; sodium nitrite in water 0 deg C, 30 min -> 20 deg C, 30 min;
参考文献
Barton, Anne; Breukelman, Stephen P.; Kaye, Perry T.; Meakins, G. Denis; Morgan, David J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 159 - 164
反应条件
copper(I) bromide; isopentyl nitrite in acetonitrile T=80°C; 3 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; UNIVERSITÉ DE MONTRÉAL; BANVILLE, Jacques; RÉMILLARD, Roger; RUEDIGER, Edward H.; DEON, Daniel H.; GAGNON, Marc; DUBÉ, Laurence; GUY, Julia; PRIESTLEY, Eldon Scott; POSY, Shoshana L.; MAXWELL, Brad D.; WONG, Pancras C.
Patent: WO2013/163279 A1, 2013 ;
Location in patent: Paragraph 00192 ;
反应条件
hypophosphorous acid; sodium nitrite in water
T=0°C; 1 h;
参考文献
Barton, Anne; Breukelman, Stephen P.; Kaye, Perry T.; Meakins, G. Denis; Morgan, David J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 159 - 164
反应条件
1: NaNO2; H3PO2
2: aq. LiOH / methanol
View Scheme
参考文献
Cui, Yong-Mei; Huang, Qing-Qing; Xu, Jie; Chen, Ling-Ling; Li, Jing-Ya; Ye, Qi-Zhuang; Li, Jia; Nan, Fa-Jun
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 16 p. 3732 - 3736
