5-异丙基噻唑-4-羧酸甲酯合成路线 (共 2 条)
反应条件
hypophosphorous acid; sodium nitrite in water
T=0°C; 1 h;
参考文献
Barton, Anne; Breukelman, Stephen P.; Kaye, Perry T.; Meakins, G. Denis; Morgan, David J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 159 - 164
反应条件
lithium hydroxide in methanol
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/147188 A1, 2009 ;
Location in patent: Page/Page column 119-120 ;
WO 2009/147188 A1