2-(3-溴苯基)-2-甲基丙酸合成路线 （共 6 条）
反应条件
1: 2-(3-bromophenyl)-propionic acid With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene
T=0°C; 1.25 h;
2: methyl iodide in tetrahydrofuran; n-heptane; ethylbenzene
15 h;
3: With hydrogenchloride; sodium hydroxide
more than 3 stages;
参考文献
AVENTIS PHARMACEUTICALS INC.
Patent: WO2006/44732 A2, 2006 ;
Location in patent: Page/Page column 173-174 ;
WO 2006/044732 A2
反应条件
1: 2-(3-bromophenyl)-propionic acid With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene
T=0°C; 1.25 h;
2: methyl iodide in tetrahydrofuran; n-heptane; ethylbenzene
15.1667 h;
3: With hydrogenchloride; water in tetrahydrofuran; n-heptane; ethylbenzene
参考文献
SANOFI-AVENTIS U.S. LLC
Patent: WO2008/39882 A1, 2008 ;
Location in patent: Page/Page column 172-173 ;
WO 2008/039882 A1
反应条件
1: With methanol; sodium hydroxide in tetrahydrofuran
2 h; Reflux;
2: With hydrogenchloride in water
参考文献
UCB PHARMA S.A.; BUeRLI, Roland; HAUGHAN, Alan, Findlay; MACK, Stephen, Robert; PERRY, Benjamin, Garfield; RAPHY, Gilles; SAVILLE-STONES, Elizabeth, Anne
Patent: WO2010/52448 A2, 2010 ;
Location in patent: Page/Page column 37 ;
WO 2010/052448 A2
反应条件
1: With sodium hydroxide; ethanol
Heating / reflux;
2: With hydrogenchloride in water
参考文献
Dyckman, Alaric; Pitts, William J.; Belema, Makonen; Gill, Patrice; Kempson, James; Qiu, Yuping; Quesnelle, Claude; Spergel, Steven H.; Zusi, F. Christopher
Patent: US2006/106051 A1, 2006 ;
Location in patent: Page/Page column 29 ;
反应条件
1: With tert.-butyl lithium in diethyl ether; pentane
T=-78°C; 0.5 h;
2: With tributoxyborane in diethyl ether; pentane
T=-78 - 20°C; 15 h;
3: With phosphoric acid; water in diethyl ether; pentane
参考文献
SANOFI-AVENTIS
Patent: WO2007/121280 A1, 2007 ;
Location in patent: Page/Page column 32 ;
WO 2007/121280 A1
反应条件
1: α-(3-bromophenyl)-α,α-dimethylacetic acid With tert.-butyl lithium in diethyl ether; pentane
T=-78°C; 0.5 h;
2: tributoxyborane in diethyl ether; pentane
T=20°C; 15 h;
3: With phosphoric acid; water in diethyl ether; pentane
参考文献
AVENTIS PHARMACEUTICALS INC
Patent: US2008/194600 A1, 2008 ;
Location in patent: Page/Page column 7 ;
