4-(羟基甲基)噻吩-2-羧酸甲酯合成路线 （共 5 条）
反应条件
sodium hydroxide in methanol; water T=20°C; 1 h;
参考文献
JE IL PHARMACEUTICAL CO., LTD.
Patent: WO2004/113281 A1, 2004 ;
Location in patent: Page 75 ;
反应条件
water; silver nitrate in 1,4-dioxane
T=20°C; 12 h;
参考文献
JE IL PHARMACEUTICAL CO., LTD.
Patent: WO2004/113281 A1, 2004 ;
Location in patent: Page 75 ;
反应条件
hydrogenchloride in water
12 h; Heating / reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/24834 A1, 2006 ;
Location in patent: Page/Page column 79 ;
WO 2006/024834 A1
反应条件
hydrogenchloride; methanol; water
12 h; Heating / reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/40568 A1, 2006 ;
Location in patent: Page/Page column 79-80 ;
WO 2006/040568 A1
反应条件
1: With phosphorus tribromide in tetrahydrofuran
T=25°C; 1 h;
2: With sodium hydrogencarbonate in tetrahydrofuran; water
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/24834 A1, 2006 ;
Location in patent: Page/Page column 80 ;
WO 2006/024834 A1
